PLCZ1

Gene Symbol	PLCZ1
Entrez Gene	89869
Alt Symbol	NYD-SP27, PLC-zeta-1, PLCzeta
Species	Human
Gene Type	protein-coding
Description	phospholipase C, zeta 1
Other Description	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1|PI-phospholipase C zeta 1|PLC-zeta-1|phosphoinositide phospholipase C-zeta-1|testis-development related NYD-SP27
Swissprots	Q86YW0 Q96J70 Q08AQ7
Accessions	CAX52143 CBF62933 CBF74664 CBH19415 CBH30749 CBU87809 CBU96756 EAW96388 EAW96389 EAW96390 Q86YW0 AF532185 AAN71895 AK097555 BAC05099 AK097725 BAC05152 AK292279 BAF84968 AK314516 AY035866 AAK61372 BC125067 AAI25068 DB038101 HY197954 XM_005253519 XP_005253576 XM_005253523 XP_005253580 XM_011520872 XP_011519174 XM_011520873 XP_011519175 XM_011520874 XP_011519176 XM_011520875 XP_011519177 XM_011520876 XP_011519178 XM_011520877 XP_011519179 XM_011520878 XP_011519180 XM_011520879 XP_011519181 XM_011520880 XP_011519182 XM_011520881 XP_011519183 XM_011520882 XP_011519184 XM_011520883 XP_011519185 XM_011520884 XP_011519186 XR_931330 XR_931332 NM_033123 NP_149114 NR_073075
Function	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805, ECO:0000269|PubMed:15579586, ECO:0000305}.
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250|UniProtKB:Q8K4D7}.
Tissue Specificity	Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic- duct cells from patients with cystic fibrosis. {ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805}.
Top Pathways	Calcium signaling pathway, Oocyte meiosis, Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PLCZ1 ELISA Kit (Sandwich ELISA) - LS-F9471 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.117 ng/ml Range 0.313-20 ng/ml

Human PLCz1 ELISA Kit - abx152776 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml Range 0.313 ng/ml - 20 ng/ml

1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase zeta-1 (PLCZ1), Human, ELISA Kit - E01P0911 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/ml

Phospholipase C Zeta 1 (PLCz1), Human, ELISA Kit - SED847Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.117ng/mL Range 0.312-20ng/mL

1 phosphatidylinositol 4, 5 bisphosphate phosphodiesterase zeta 1, ELISA Kit - MBS7223645 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS062748 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS056359 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS087095 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS098117 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS049252 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS067177 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS056687 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS081264 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS079224 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS080760 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS087423 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS095640 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS062886 from MyBioSource Category ELISA Kit Prices $435.00, $600.00 Sizes 48 strip wells, 96 strip wells

Phospholipase C Zeta 1, ELISA Kit - MBS078262 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS097729 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS065987 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS074182 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS071624 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS106715 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Phospholipase C Zeta 1, ELISA Kit - MBS072674 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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