PLCZ1

Gene Symbol PLCZ1
Entrez Gene 89869
Alt Symbol NYD-SP27, PLC-zeta-1, PLCzeta
Species Human
Gene Type protein-coding
Description phospholipase C, zeta 1
Other Description 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1|PI-phospholipase C zeta 1|PLC-zeta-1|phosphoinositide phospholipase C-zeta-1|testis-development related NYD-SP27
Swissprots Q86YW0 Q96J70 Q08AQ7
Accessions CAX52143 CBF62933 CBF74664 CBH19415 CBH30749 CBU87809 CBU96756 EAW96388 EAW96389 EAW96390 Q86YW0 AF532185 AAN71895 AK097555 BAC05099 AK097725 BAC05152 AK292279 BAF84968 AK314516 AY035866 AAK61372 BC125067 AAI25068 DB038101 HY197954 XM_005253519 XP_005253576 XM_005253523 XP_005253580 XM_011520872 XP_011519174 XM_011520873 XP_011519175 XM_011520874 XP_011519176 XM_011520875 XP_011519177 XM_011520876 XP_011519178 XM_011520877 XP_011519179 XM_011520878 XP_011519180 XM_011520879 XP_011519181 XM_011520880 XP_011519182 XM_011520881 XP_011519183 XM_011520882 XP_011519184 XM_011520883 XP_011519185 XM_011520884 XP_011519186 XR_931330 XR_931332 NM_033123 NP_149114 NR_073075
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805, ECO:0000269|PubMed:15579586, ECO:0000305}.
Subcellular Location Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250|UniProtKB:Q8K4D7}.
Tissue Specificity Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic- duct cells from patients with cystic fibrosis. {ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805}.
Top Pathways Calcium signaling pathway, Oocyte meiosis, Inositol phosphate metabolism, Phosphatidylinositol signaling system

PLCZ1 protein (His-DHFR tag) - ab127842 from Abcam

Category Protein
Source E. coli
Species Human

PLCZ1 Blocking Peptide - LS-E10123 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PLCZ1-Antibody-N-term-Blocking-Peptide - BP9423a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Human PLCZ1 protein - orb244867 from Biorbyt

Category Protein
Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00
Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg
Species Human

PLCZ1 fusion protein - Ag17849 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human PLCZ1, His-tagged - PLCZ1-1769H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Phospholipase C Zeta 1 (PLCz1) - RPD847Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant Phospholipase C Zeta 1 (PLCz1) - RPD847Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1(PLCZ1) - CSB-YP768240HU CSB-BP768240HU CSB-MP768240HU from Cusabio

Category Protein
Source Yeast or Baculovirus or Mammalian cell
Species Human

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1, Recombinant Protein - MBS1451131 from MyBioSource

Category Protein
Prices $180.00, $490.00, $715.00, $950.00, $1,170.00, $1,170.00, $1,170.00, $1,390.00, $1,850.00, $1,850.00
Sizes 50 µg (Mammalian-Cell), 50 µg (Baculovirus), 100 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 100 µg (Mammalian-Cell), 1 mg (E-Coli), 200 µg (E-Coli), 50 µg (E-Coli), 1 mg (Yeast)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

PLCZ1 Peptide, Human - M34GP11911H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

PLCZ1 Recombinant Protein (OPCA02330) - OPCA02330 from Aviva Systems Biology

Category Protein
Prices $250.00
Sizes 50 µg
Source Human

Recombinant human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 - AP71371 from Signalway Antibody

Category Protein
Prices $260.00, $735.00, $1,240.00, $1,975.00
Sizes 50 µg, 200 µg, 500 µg, 1 mg
Source E.coli
Species Human

1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase zeta-1, Recombinant Protein - MBS9421238 from MyBioSource

Category Protein
Prices $280.00, $665.00, $1,080.00, $1,690.00
Sizes 50 µg, 200 µg, 500 µg, 1 mg
Source E Coli
Species Human

PLCZ1 fusion protein - Ag26899 from Proteintech Group

Category Protein
Source E. coli -derived, PET28a
Species Human
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