PLCZ1

Gene Symbol PLCZ1
Entrez Gene 89869
Alt Symbol NYD-SP27, PLC-zeta-1, PLCzeta
Species Human
Gene Type protein-coding
Description phospholipase C, zeta 1
Other Description 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1|PI-phospholipase C zeta 1|PLC-zeta-1|phosphoinositide phospholipase C-zeta-1|testis-development related NYD-SP27
Swissprots Q86YW0 Q96J70 Q08AQ7
Accessions CAX52143 CBF62933 CBF74664 CBH19415 CBH30749 CBU87809 CBU96756 EAW96388 EAW96389 EAW96390 Q86YW0 AF532185 AAN71895 AK097555 BAC05099 AK097725 BAC05152 AK292279 BAF84968 AK314516 AY035866 AAK61372 BC125067 AAI25068 DB038101 HY197954 XM_005253519 XP_005253576 XM_005253523 XP_005253580 XM_011520872 XP_011519174 XM_011520873 XP_011519175 XM_011520874 XP_011519176 XM_011520875 XP_011519177 XM_011520876 XP_011519178 XM_011520877 XP_011519179 XM_011520878 XP_011519180 XM_011520879 XP_011519181 XM_011520880 XP_011519182 XM_011520881 XP_011519183 XM_011520882 XP_011519184 XM_011520883 XP_011519185 XM_011520884 XP_011519186 XR_931330 XR_931332 NM_033123 NP_149114 NR_073075
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805, ECO:0000269|PubMed:15579586, ECO:0000305}.
Subcellular Location Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250|UniProtKB:Q8K4D7}.
Tissue Specificity Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic- duct cells from patients with cystic fibrosis. {ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805}.
Top Pathways Calcium signaling pathway, Oocyte meiosis, Inositol phosphate metabolism, Phosphatidylinositol signaling system

PLC ζ (C-12) - sc-131752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PLCZ1 antibody - ab124446 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab124446 at 1/100 dilution staining PLCZ1 in Human fetal testis tissue by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-PLCZ1 antibody - ab181816 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human uterus endometrium tissue labeling PLCZ1 with ab181816 at 10 µg/ml.

Anti-PLCZ1 Antibody (Internal) - LS-C144827 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCZ1 Antibody (Internal) IHC-plus™ - LS-B8469 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human, Uterus: Formalin-Fixed Paraffin-Embedded (FFPE)

Anti-PLCZ1 Antibody (aa322-572) - LS-C178950 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLCZ1 Antibody - NBP1-80982 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PLCZ1 Antibody [NBP1-80982] - Staining of human testis shows moderate cytoplasmic positivity in cells in seminiferus ducts.

PLCZ1 Polyclonal Antibody - bs-5378R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat testis tissue labeled with Anti-PLCZ1 Polyclonal Antibody, Unconjugated(bs-5378R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

ANTI-PLCZ1 (N-TERM) antibody produced in rabbit - SAB1304307 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PLCZ1 (N-term): <B>Cat. No. SAB1304307</B>: Western blot analysis of PLCZ1 Antibody (N-term) in cell line lysates (35 μg/lane).<BR/><B>Lanes:</B><BR/>1. CEM<BR/>2. HEK_293 cell line<BR/>3. mouse heart<BR/>4. spleen tissue lysates

Anti-PLCZ1 antibody produced in rabbit - SAB4301008 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLCZ1-Antibody-N-term - AP9423a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of PLCZ1 Antibody (N-term) (Cat. #AP9423a) in CEM, 293 cell line and mouse heart,spleen tissue lysates (35ug/lane). PLCZ1 (arrow) was detected using the purified Pab.

PLCZ1 antibody - orb78246 from Biorbyt

Prices $425.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of fetal kidney,fetal liverlysate and Hela cell lysate using PLCZ1 antibody

PLCZ1 Antibody (OABF01559) - OABF01559 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLCZ1 antibody - 70R-35654 from Fitzgerald

Host Rabbit
Clonality Polyclonal

PLCZ1 Antibody - abx034368 from Abbexa

Host Rabbit
Clonality Polyclonal

PLCZ1 Antibody - abx037255 from Abbexa

Host Rabbit
Clonality Polyclonal

PLCZ1 antibody - AP55157SU-N from Acris Antibodies

Prices $460.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

PLCZ1 antibody (N-term) - STJ51945 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB24781

PLCZ1 Antibody - 36697 from Signalway Antibody

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using #36697 at dilution 1/25.

PLCZ1 Antibody - E306226 from Enogene

Prices $275.00
Sizes 100ug/200ul

PLCZ1 Polyclonal Antibody - ESAP11658 from Elabscience

Prices $296.00, $485.00
Sizes 120 μl, 200 μl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human lung cancer using PLCZ1 Polyclonal Antibody at dilution of 1:25

PLCZ1 Polyclonal Antibody - ESAP15603 from Elabscience

Prices $296.00, $485.00
Sizes 120 μl, 200 μl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human colon cancer using PLCZ1 Polyclonal Antibody at dilution of 1:20

Anti-PLCZ1 (internal region) polyclonal antibody - DPABH-13813 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-PLCZ1 (aa 322-572) polyclonal antibody - DPABH-22018 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Monoclonal Antibody to Phospholipase C Zeta 1 (PLCz1) - MAD847Hu21 from Uscn Life Science Inc.

Host Mouse
Clonality Monoclonal
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