| Gene Symbol |
PLCZ1
|
| Entrez Gene |
89869
|
| Alt Symbol |
NYD-SP27, PLC-zeta-1, PLCzeta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C, zeta 1
|
| Other Description |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1|PI-phospholipase C zeta 1|PLC-zeta-1|phosphoinositide phospholipase C-zeta-1|testis-development related NYD-SP27
|
| Swissprots |
Q86YW0 Q96J70 Q08AQ7
|
| Accessions |
CAX52143 CBF62933 CBF74664 CBH19415 CBH30749 CBU87809 CBU96756 EAW96388 EAW96389 EAW96390 Q86YW0 AF532185 AAN71895 AK097555 BAC05099 AK097725 BAC05152 AK292279 BAF84968 AK314516 AY035866 AAK61372 BC125067 AAI25068 DB038101 HY197954 XM_005253519 XP_005253576 XM_005253523 XP_005253580 XM_011520872 XP_011519174 XM_011520873 XP_011519175 XM_011520874 XP_011519176 XM_011520875 XP_011519177 XM_011520876 XP_011519178 XM_011520877 XP_011519179 XM_011520878 XP_011519180 XM_011520879 XP_011519181 XM_011520880 XP_011519182 XM_011520881 XP_011519183 XM_011520882 XP_011519184 XM_011520883 XP_011519185 XM_011520884 XP_011519186 XR_931330 XR_931332 NM_033123 NP_149114 NR_073075
|
| Function |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805, ECO:0000269|PubMed:15579586, ECO:0000305}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250|UniProtKB:Q8K4D7}.
|
| Tissue Specificity |
Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic- duct cells from patients with cystic fibrosis. {ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805}.
|
| Top Pathways |
Calcium signaling pathway, Oocyte meiosis, Inositol phosphate metabolism, Phosphatidylinositol signaling system
|