| Gene Symbol |
DAPK2
|
| Entrez Gene |
23604
|
| Alt Symbol |
DRP-1, DRP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
death-associated protein kinase 2
|
| Other Description |
DAP kinase 2|DAP-kinase-related protein 1 beta isoform
|
| Swissprots |
Q24JS1 O75892 E9JGM7 Q9UIK4
|
| Accessions |
EAW77657 EAW77658 EAW77659 Q9UIK4 AB018001 BAA88063 AF052941 AAC35001 AK026801 AK094290 AK310967 BC114506 AAI14507 BC114951 AAI14952 GU056176 ADD83109 XM_006720452 XP_006720515 XM_006720453 XP_006720516 XM_011521410 XP_011519712 XM_011521411 XP_011519713 XM_011521412 XP_011519714 XM_011521413 XP_011519715 XM_011521414 XP_011519716 XM_011521415 XP_011519717 XM_011521416 XP_011519718 XM_011521417 XP_011519719 XM_011521418 XP_011519720 XM_011521419 XP_011519721 XM_011521420 XP_011519722 XM_011521421 XP_011519723 NM_014326 NP_055141
|
| Function |
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation.
|
| Subcellular Location |
Cytoplasm. Cytoplasmic vesicle, autophagosome lumen.
|
| Tissue Specificity |
Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle. It is expressed abundantly in cells differentiated toward granulocytes and low in undifferentiated, normal and leukemic hematopoietic cells and monocytes/macrophages. {ECO:0000269|PubMed:10376525, ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:21408167}.
|
| Top Pathways |
Bladder cancer
|