DAPK2
| Gene Symbol | DAPK2 |
|---|---|
| Entrez Gene | 23604 |
| Alt Symbol | DRP-1, DRP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | death-associated protein kinase 2 |
| Other Description | DAP kinase 2|DAP-kinase-related protein 1 beta isoform |
| Swissprots | Q24JS1 O75892 E9JGM7 Q9UIK4 |
| Accessions | EAW77657 EAW77658 EAW77659 Q9UIK4 AB018001 BAA88063 AF052941 AAC35001 AK026801 AK094290 AK310967 BC114506 AAI14507 BC114951 AAI14952 GU056176 ADD83109 XM_006720452 XP_006720515 XM_006720453 XP_006720516 XM_011521410 XP_011519712 XM_011521411 XP_011519713 XM_011521412 XP_011519714 XM_011521413 XP_011519715 XM_011521414 XP_011519716 XM_011521415 XP_011519717 XM_011521416 XP_011519718 XM_011521417 XP_011519719 XM_011521418 XP_011519720 XM_011521419 XP_011519721 XM_011521420 XP_011519722 XM_011521421 XP_011519723 NM_014326 NP_055141 |
| Function | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. |
| Subcellular Location | Cytoplasm. Cytoplasmic vesicle, autophagosome lumen. |
| Tissue Specificity | Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle. It is expressed abundantly in cells differentiated toward granulocytes and low in undifferentiated, normal and leukemic hematopoietic cells and monocytes/macrophages. {ECO:0000269|PubMed:10376525, ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:21408167}. |
| Top Pathways | Bladder cancer |
DAPK2 CRISPR/Cas9 KO Plasmid (h) - sc-404468 from Santa Cruz Biotechnology
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DAPK2 HDR Plasmid (h) - sc-404468-HDR from Santa Cruz Biotechnology
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DAPK2 Double Nickase Plasmid (h) - sc-404468-NIC from Santa Cruz Biotechnology
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DAPK2 Double Nickase Plasmid (h2) - sc-404468-NIC-2 from Santa Cruz Biotechnology
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DAPK2 CRISPR Activation Plasmid (h) - sc-404468-ACT from Santa Cruz Biotechnology
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DAPK2 CRISPR Activation Plasmid (h2) - sc-404468-ACT-2 from Santa Cruz Biotechnology
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DAPK2 Lentiviral Activation Particles (h) - sc-404468-LAC from Santa Cruz Biotechnology
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DAPK2 Lentiviral Activation Particles (h2) - sc-404468-LAC-2 from Santa Cruz Biotechnology
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DAPK2 siRNA (h) - sc-38978 from Santa Cruz Biotechnology
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DAPK2 shRNA Plasmid (h) - sc-38978-SH from Santa Cruz Biotechnology
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DAPK2 shRNA (h) Lentiviral Particles - sc-38978-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU036031 from Sigma-Aldrich
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MISSION® siRNA - SIHK0541 from Sigma-Aldrich
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MISSION® siRNA - SIHK0542 from Sigma-Aldrich
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MISSION® siRNA - SIHK0543 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6928 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6928 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09739 from Sigma-Aldrich
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DAPK2 siRNA (Human) - CRH8392 from Cohesion Biosciences
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DAP Kinase 2 RNAi - H00023604-R02 from Novus Biologicals
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DAPK2 - MBS8214815 from MyBioSource
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shRNA set against Human DAPK2 (NM_014326.3) - SHH274545 from Creative biogene
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shRNA set against Human DAPK2(NM_014326.3) - SHG221635 from Creative biogene
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Human DAPK2 siRNA - orb268894 from Biorbyt
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DAPK2 shRNA Plasmid (Human) - CHH8392 from Cohesion Biosciences
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