DAPK2

Gene Symbol	DAPK2
Entrez Gene	23604
Alt Symbol	DRP-1, DRP1
Species	Human
Gene Type	protein-coding
Description	death-associated protein kinase 2
Other Description	DAP kinase 2|DAP-kinase-related protein 1 beta isoform
Swissprots	Q24JS1 O75892 E9JGM7 Q9UIK4
Accessions	EAW77657 EAW77658 EAW77659 Q9UIK4 AB018001 BAA88063 AF052941 AAC35001 AK026801 AK094290 AK310967 BC114506 AAI14507 BC114951 AAI14952 GU056176 ADD83109 XM_006720452 XP_006720515 XM_006720453 XP_006720516 XM_011521410 XP_011519712 XM_011521411 XP_011519713 XM_011521412 XP_011519714 XM_011521413 XP_011519715 XM_011521414 XP_011519716 XM_011521415 XP_011519717 XM_011521416 XP_011519718 XM_011521417 XP_011519719 XM_011521418 XP_011519720 XM_011521419 XP_011519721 XM_011521420 XP_011519722 XM_011521421 XP_011519723 NM_014326 NP_055141
Function	Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation.
Subcellular Location	Cytoplasm. Cytoplasmic vesicle, autophagosome lumen.
Tissue Specificity	Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle. It is expressed abundantly in cells differentiated toward granulocytes and low in undifferentiated, normal and leukemic hematopoietic cells and monocytes/macrophages. {ECO:0000269|PubMed:10376525, ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:21408167}.
Top Pathways	Bladder cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DAP Kinase 2 full length protein - ab89742 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

DAP Kinase 2 peptide - ab8436 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human DAP Kinase 2 peptide - ab22865 from Abcam Category Peptide Species Human

Human DAP Kinase 2 protein fragment - ab153241 from Abcam Category Protein Source Wheat germ Species Human

DAPK2 / DAP Kinase 2 Antibody Blocking Peptide - LS-E3517 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAPK2 / DAP Kinase 2 Antibody Blocking Peptide - LS-E25282 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAPK2 / DAP Kinase 2 Antibody Blocking Peptide - LS-E8774 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAPK2 / DAP Kinase 2 Antibody Blocking Peptide - LS-E29944 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human DAP Kinase 2 Protein - H00023604-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DAP Kinase 2 Blocking Peptide - NBP1-77291PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

DAPK2-Antibody-N-term-Blocking-Peptide - BP7218a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DAP Kinase 2 blocking peptide - GTX89970-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

DAP Kinase 2 Peptide - AC21-0110-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DAPK2 / DRP-1 - H00023604-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DAPK2 / DRP-1 - H00023604-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DAPK2 / DRP-1 Control Peptide - AP30272CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DAP kinase 2 Peptide - 2323P from ProSci Category Peptide Species Human

DAPK2 Peptide - 45-047P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

DAPK2 fusion protein - ag18105 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DAPK2 fusion protein - ag18185 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human DAPK2, GST-tagged, Active - DAPK2-290H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human DAPK2 - DAPK2-26805TH from Creative Biomart Category Protein Species Human

Recombinant Human Death-Associated Protein Kinase 2, His-tagged - DAPK2-675H from Creative Biomart Category Protein Source Insect cells Species Human

DAPK2 Protein, active, 10 µg - 14-657 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg Source expressed by baculovirus in Sf21 cells

DAPK2 (R314) Peptide - BS1628P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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