| Gene Symbol |
AIMP2
|
| Entrez Gene |
7965
|
| Alt Symbol |
JTV-1, JTV1, P38, PRO0992
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
|
| Other Description |
ARS-interacting multi-functional protein 2|aminoacyl tRNA synthase complex-interacting multifunctional protein 2|multisynthase complex auxiliary component p38|multisynthetase complex auxiliary component p38|protein JTV-1
|
| Swissprots |
Q13155 Q96CZ5 Q75MR1 Q9P1L2
|
| Accessions |
AAS00389 EAL23713 EAW55053 EAW55054 Q13155 AF116615 AAF71039 AK313037 BAG35870 BC002853 AAH02853 BC010156 AAH10156 BC013630 AAH13630 U24169 AAC50391 XM_005249847 XP_005249904 XM_005249848 XP_005249905 XM_005249850 XP_005249907 XM_006715772 XP_006715835 XM_011515519 XP_011513821 NM_006303 NP_006294
|
| Function |
Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250}.
|
