Gene Symbol | Spz1 |
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Entrez Gene | 79401 |
Alt Symbol | 1700027M20Rik, AI429130 |
Species | Mouse |
Gene Type | protein-coding |
Description | spermatogenic leucine zipper 1 |
Other Description | bhlh-zip transcription factor SPZ1|spermatogenic Zip 1|spermatogenic leucine zipper protein 1 |
Swissprots | Q80X69 Q3V487 Q99MY0 |
Accessions | EDL00954 Q99MY0 AF271697 AAK15458 AK006437 BAE43195 BC050748 AAH50748 NM_030237 NP_084513 |
Function | Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine- rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:14980513, ECO:0000269|PubMed:15899793}. |
Subcellular Location | Cytoplasm. Nucleus. |
Tissue Specificity | Expressed specifically in the testis and epidydimis. In the testis expressed in both germ cells and somatic cells (Sertoli and Leydig cells). Expressed in several tumor cell lines. {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:14980513, ECO:0000269|PubMed:15899793}. |
SPZ1 (Q-15) - sc-107300 from Santa Cruz Biotechnology
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Anti-SPZ1 antibody - ab50870 from Abcam
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SPZ1 Antibody - NBP1-80253 from Novus Biologicals
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Anti-SPZ1 antibody produced in rabbit - AV37405 from Sigma-Aldrich
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SPZ1 antibody - C-terminal region (ARP37405_T100) - ARP37405_T100 from Aviva Systems Biology
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SPZ1 antibody - 70R-32108 from Fitzgerald
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SPZ1 antibody - 20R-1158 from Fitzgerald
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SPZ1 Antibody - 28-669 from ProSci
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SPZ1, Polyclonal Antibody - MBS833148 from MyBioSource
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SPZ1 Antibody - GWB-752EA7 from Genway Biotech
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SPZ1 / TSP1 antibody - TA329956 from Acris Antibodies
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Anti-SPZ1 (aa 325-374) polyclonal antibody - CABT-BL5745 from Creative Diagnostics
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SPZ1 antibody - C-terminal region : Biotin (ARP37405_T100-Biotin) - ARP37405_T100-Biotin from Aviva Systems Biology
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SPZ1 antibody - C-terminal region : FITC (ARP37405_T100-FITC) - ARP37405_T100-FITC from Aviva Systems Biology
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SPZ1 antibody - C-terminal region : HRP (ARP37405_T100-HRP) - ARP37405_T100-HRP from Aviva Systems Biology
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