Gene Symbol | Spz1 |
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Entrez Gene | 79401 |
Alt Symbol | 1700027M20Rik, AI429130 |
Species | Mouse |
Gene Type | protein-coding |
Description | spermatogenic leucine zipper 1 |
Other Description | bhlh-zip transcription factor SPZ1|spermatogenic Zip 1|spermatogenic leucine zipper protein 1 |
Swissprots | Q80X69 Q3V487 Q99MY0 |
Accessions | EDL00954 Q99MY0 AF271697 AAK15458 AK006437 BAE43195 BC050748 AAH50748 NM_030237 NP_084513 |
Function | Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine- rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:14980513, ECO:0000269|PubMed:15899793}. |
Subcellular Location | Cytoplasm. Nucleus. |
Tissue Specificity | Expressed specifically in the testis and epidydimis. In the testis expressed in both germ cells and somatic cells (Sertoli and Leydig cells). Expressed in several tumor cell lines. {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:14980513, ECO:0000269|PubMed:15899793}. |
SPZ1 CRISPR/Cas9 KO Plasmid (m) - sc-429772 from Santa Cruz Biotechnology
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SPZ1 HDR Plasmid (m) - sc-429772-HDR from Santa Cruz Biotechnology
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SPZ1 Double Nickase Plasmid (m) - sc-429772-NIC from Santa Cruz Biotechnology
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SPZ1 Double Nickase Plasmid (m2) - sc-429772-NIC-2 from Santa Cruz Biotechnology
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SPZ1 CRISPR Activation Plasmid (m) - sc-429772-ACT from Santa Cruz Biotechnology
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SPZ1 CRISPR Activation Plasmid (m2) - sc-429772-ACT-2 from Santa Cruz Biotechnology
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SPZ1 Lentiviral Activation Particles (m) - sc-429772-LAC from Santa Cruz Biotechnology
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SPZ1 Lentiviral Activation Particles (m2) - sc-429772-LAC-2 from Santa Cruz Biotechnology
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SPZ1 siRNA (m) - sc-153811 from Santa Cruz Biotechnology
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SPZ1 shRNA Plasmid (m) - sc-153811-SH from Santa Cruz Biotechnology
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SPZ1 shRNA (m) Lentiviral Particles - sc-153811-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU008061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42013 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42013 from Sigma-Aldrich
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SPZ1 siRNA (Mouse) - CRN0031 from Cohesion Biosciences
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SPZ1 - MBS8234795 from MyBioSource
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shRNA set against Mouse SPZ1 (NM_030237.3) - SHH417580 from Creative biogene
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SPZ1 shRNA Plasmid (Mouse) - CHN0031 from Cohesion Biosciences
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