Gene Symbol | Spz1 |
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Entrez Gene | 79401 |
Alt Symbol | 1700027M20Rik, AI429130 |
Species | Mouse |
Gene Type | protein-coding |
Description | spermatogenic leucine zipper 1 |
Other Description | bhlh-zip transcription factor SPZ1|spermatogenic Zip 1|spermatogenic leucine zipper protein 1 |
Swissprots | Q80X69 Q3V487 Q99MY0 |
Accessions | EDL00954 Q99MY0 AF271697 AAK15458 AK006437 BAE43195 BC050748 AAH50748 NM_030237 NP_084513 |
Function | Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine- rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:14980513, ECO:0000269|PubMed:15899793}. |
Subcellular Location | Cytoplasm. Nucleus. |
Tissue Specificity | Expressed specifically in the testis and epidydimis. In the testis expressed in both germ cells and somatic cells (Sertoli and Leydig cells). Expressed in several tumor cell lines. {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:14980513, ECO:0000269|PubMed:15899793}. |
Recombinant Mouse Spermatogenic leucine zipper protein 1(Spz1) - CSB-YP858159MO CSB-EP858159MO CSB-BP858159MO CSB-MP858159MO from Cusabio
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Recombinant Mouse SPZ1 Protein - SPZ1-15961M from Creative Biomart
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Spermatogenic leucine zipper protein 1 (Spz1), Recombinant Protein - MBS1286857 from MyBioSource
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