| Gene Symbol |
Spz1
|
| Entrez Gene |
79401
|
| Alt Symbol |
1700027M20Rik, AI429130
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
spermatogenic leucine zipper 1
|
| Other Description |
bhlh-zip transcription factor SPZ1|spermatogenic Zip 1|spermatogenic leucine zipper protein 1
|
| Swissprots |
Q80X69 Q3V487 Q99MY0
|
| Accessions |
EDL00954 Q99MY0 AF271697 AAK15458 AK006437 BAE43195 BC050748 AAH50748 NM_030237 NP_084513
|
| Function |
Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine- rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:14980513, ECO:0000269|PubMed:15899793}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Expressed specifically in the testis and epidydimis. In the testis expressed in both germ cells and somatic cells (Sertoli and Leydig cells). Expressed in several tumor cell lines. {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:14980513, ECO:0000269|PubMed:15899793}.
|