| Gene Symbol |
SLC22A17
|
| Entrez Gene |
51310
|
| Alt Symbol |
24p3R, BOCT, BOIT, NGALR, NGALR2, NGALR3, hBOIT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 22, member 17
|
| Other Description |
24p3 receptor|NGAL receptor|brain-type organic cation transporter|lipocalin-2 receptor|neutrophil gelatinase-associated lipocalin receptor|potent brain type organic ion transporter|solute carrier family 22 (organic cation transporter), member 17|solute carrier family 22 member 17
|
| Swissprots |
A8MUT0 Q9NQD5 Q9H1D3 A4UA13 Q5BKY8 Q2TAB0 Q86U04 Q8WUG5
|
| Accessions |
CAC17762 EAW66165 EAW66166 Q8WUG5 AJ243653 CAC01119 AK308661 AK311241 BC020565 AAH20565 BC030559 BC090870 AAH90870 BC111015 AAI11016 BF345519 BI758221 BX161416 CAD61891 BX647316 DQ658848 ABG45942 JF432878 ADZ16095 XM_005267747 XP_005267804 XM_005267748 XP_005267805 XR_245694 NM_001289050 NP_001275979 NM_016609 NP_057693 NM_020372 NP_065105 NR_110290
|
| Function |
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Vacuole membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Note=Upon LCN2-binding, it is internalized.
|
| Tissue Specificity |
Expressed in brain.
|