SLC22A17
| Gene Symbol | SLC22A17 |
|---|---|
| Entrez Gene | 51310 |
| Alt Symbol | 24p3R, BOCT, BOIT, NGALR, NGALR2, NGALR3, hBOIT |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 22, member 17 |
| Other Description | 24p3 receptor|NGAL receptor|brain-type organic cation transporter|lipocalin-2 receptor|neutrophil gelatinase-associated lipocalin receptor|potent brain type organic ion transporter|solute carrier family 22 (organic cation transporter), member 17|solute carrier family 22 member 17 |
| Swissprots | A8MUT0 Q9NQD5 Q9H1D3 A4UA13 Q5BKY8 Q2TAB0 Q86U04 Q8WUG5 |
| Accessions | CAC17762 EAW66165 EAW66166 Q8WUG5 AJ243653 CAC01119 AK308661 AK311241 BC020565 AAH20565 BC030559 BC090870 AAH90870 BC111015 AAI11016 BF345519 BI758221 BX161416 CAD61891 BX647316 DQ658848 ABG45942 JF432878 ADZ16095 XM_005267747 XP_005267804 XM_005267748 XP_005267805 XR_245694 NM_001289050 NP_001275979 NM_016609 NP_057693 NM_020372 NP_065105 NR_110290 |
| Function | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Vacuole membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Note=Upon LCN2-binding, it is internalized. |
| Tissue Specificity | Expressed in brain. |
BOCT CRISPR/Cas9 KO Plasmid (h) - sc-402590 from Santa Cruz Biotechnology
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BOCT HDR Plasmid (h) - sc-402590-HDR from Santa Cruz Biotechnology
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BOCT Double Nickase Plasmid (h) - sc-402590-NIC from Santa Cruz Biotechnology
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BOCT Double Nickase Plasmid (h2) - sc-402590-NIC-2 from Santa Cruz Biotechnology
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BOCT CRISPR Activation Plasmid (h) - sc-402590-ACT from Santa Cruz Biotechnology
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BOCT CRISPR Activation Plasmid (h2) - sc-402590-ACT-2 from Santa Cruz Biotechnology
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BOCT Lentiviral Activation Particles (h) - sc-402590-LAC from Santa Cruz Biotechnology
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BOCT Lentiviral Activation Particles (h2) - sc-402590-LAC-2 from Santa Cruz Biotechnology
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BOCT siRNA (h) - sc-92100 from Santa Cruz Biotechnology
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BOCT shRNA Plasmid (h) - sc-92100-SH from Santa Cruz Biotechnology
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BOCT shRNA (h) Lentiviral Particles - sc-92100-V from Santa Cruz Biotechnology
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SLC22A17 RNAi - H00051310-R02 from Novus Biologicals
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SLC22A17 RNAi - H00051310-R01 from Novus Biologicals
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MISSION® esiRNA - EHU087591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19461 from Sigma-Aldrich
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SLC22A17 siRNA (Human) - CRH9687 from Cohesion Biosciences
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SLC22A17 - MBS8221280 from MyBioSource
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shRNA set against Human SLC22A17 (NM_016609.3) - SHH409084 from Creative biogene
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shRNA set against Human SLC22A17(NM_020372.2) - SHL001160 from Creative biogene
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shRNA set against Human SLC22A17(NM_016609.3) - SHL001196 from Creative biogene
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SLC22A17 shRNA Plasmid (Human) - CHH9687 from Cohesion Biosciences
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SLC22A17 miRNA 3'UTR clone - MiUTR1H-09461 from Creative biogene
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SLC22A17 miRNA 3'UTR clone - MiUTR1H-09462 from Creative biogene
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