| Gene Symbol | H3F3B |
|---|---|
| Entrez Gene | 3021 |
| Alt Symbol | H3.3B |
| Species | Human |
| Gene Type | protein-coding |
| Description | H3 histone, family 3B (H3.3B) |
| Other Description | histone H3.3 |
| Swissprots | Q5VV56 Q5VV55 P84243 Q66I33 |
| Accessions | CAA88778 EAW89317 EAW89318 EAW89319 AF218029 AAG17271 AK054591 AK130772 AK304607 BAG65392 AK312762 BAG35628 AM393192 CAL38070 BC001124 AAH01124 BC006497 AAH06497 BC012813 AAH12813 BC017558 AAH17558 BC020466 BC108701 AAI08702 BM723811 BX537379 CAD97621 BX647280 DB466880 EU446957 ABZ92486 NM_005324 NP_005315 |
| Function | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Subcellular Location | Nucleus. Chromosome. |
| Top Pathways | Systemic lupus erythematosus, Alcoholism, Transcriptional misregulation in cancer |