| Gene Symbol |
GSG2
|
| Entrez Gene |
83903
|
| Alt Symbol |
HASPIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
germ cell associated 2 (haspin)
|
| Other Description |
H-haspin|germ cell-specific gene 2 protein|haploid germ cell-specific nuclear protein kinase|serine/threonine-protein kinase haspin
|
| Swissprots |
Q9BXS7 Q8TF76 Q96MN1 Q5U5K3
|
| Accessions |
EAW90481 Q8TF76 AB039834 BAB21938 AF289865 AAK30300 AK056691 BAB71255 AK292715 BAF85404 AK310546 AK315247 BC016626 AAH16626 BC036181 BC047457 AAH47457 BC050662 NM_031965 NP_114171
|
| Function |
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.
|
| Subcellular Location |
Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.
|
| Tissue Specificity |
Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:11311556}.
|