Gene Symbol | GSG2 |
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Entrez Gene | 83903 |
Alt Symbol | HASPIN |
Species | Human |
Gene Type | protein-coding |
Description | germ cell associated 2 (haspin) |
Other Description | H-haspin|germ cell-specific gene 2 protein|haploid germ cell-specific nuclear protein kinase|serine/threonine-protein kinase haspin |
Swissprots | Q9BXS7 Q8TF76 Q96MN1 Q5U5K3 |
Accessions | EAW90481 Q8TF76 AB039834 BAB21938 AF289865 AAK30300 AK056691 BAB71255 AK292715 BAF85404 AK310546 AK315247 BC016626 AAH16626 BC036181 BC047457 AAH47457 BC050662 NM_031965 NP_114171 |
Function | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
Subcellular Location | Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis. |
Tissue Specificity | Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:11311556}. |
Active human Haspin protein fragment - ab104026 from Abcam
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Human Haspin full length protein - ab132239 from Abcam
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Human Haspin peptide - ab23532 from Abcam
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Human Haspin protein fragment - ab153547 from Abcam
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GSG2 / HASPIN Antibody Blocking Peptide - LS-E22161 from LifeSpan Bioscience
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GSG2 / HASPIN Antibody Blocking Peptide - LS-E22162 from LifeSpan Bioscience
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Recombinant Human GSG2 Protein - H00083903-P01 from Novus Biologicals
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GSG2 Partial Recombinant Protein - H00083903-Q01 from Novus Biologicals
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GSG2 Blocking Peptide - 33R-7513 from Fitzgerald
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GSG2 Blocking Peptide - 33R-10406 from Fitzgerald
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GSG2 / Haspin - H00083903-P01-10 from Acris Antibodies
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GSG2 / Haspin - H00083903-P01-25 from Acris Antibodies
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GSG2 / Haspin - H00083903-Q01-10 from Acris Antibodies
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GSG2 / Haspin - H00083903-Q01-25 from Acris Antibodies
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GSG2 / Haspin - P5558 from Acris Antibodies
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Recombinant Human Germ Cell Associated 2 (haspin), GST-tagged - GSG2-1586H from Creative Biomart
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Recombinant Human GSG2 - GSG2-29180TH from Creative Biomart
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Haspin Protein, active, 10 µg - 14-744 from EMD Millipore
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Haspin Protein, active, 250 µg - 14-744M from EMD Millipore
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Recombinant Human Serine/threonine-protein kinase haspin(GSG2) - CSB-YP819485HU CSB-EP819485HU CSB-BP819485HU CSB-MP819485HU from Cusabio
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GSG2 Protein - NBP1-81774PEP from Novus Biologicals
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GSG2-Antibody-Center-Blocking-peptide - BP8064c from Abgent, a WuXi AppTec company
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GSG2 Peptide, Human - M34GP06700H from Creative Peptides
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GSG2 Recombinant Protein Antigen - NBP2-55174PEP from Novus Biologicals
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Serine/threonine-protein kinase haspin (GSG2), Recombinant Protein - MBS1285881 from MyBioSource
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