| Gene Symbol |
CTIF
|
| Entrez Gene |
9811
|
| Alt Symbol |
Gm672, KIAA0427
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CBP80/20-dependent translation initiation factor
|
| Other Description |
-
|
| Swissprots |
Q8IVD5 O43310 B3KTR8
|
| Accessions |
EAW62925 EAW62926 EAW62927 EAW62928 O43310 AB007887 BAA24857 AK095970 BAG53180 BC042146 AAH42146 BU688371 XM_005258392 XP_005258449 XM_006722583 XP_006722646 XM_006722585 XP_006722648 XM_006722586 XP_006722649 XM_006722587 XP_006722650 XM_006722588 XP_006722651 XM_006722589 XP_006722652 XM_011526278 XP_011524580 XM_011526279 XP_011524581 XM_011526280 XP_011524582 NM_001142397 NP_001135869 NM_014772 NP_055587
|
| Function |
Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:19648179}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:19648179}.
|