| Gene Symbol |
VPS35
|
| Entrez Gene |
55737
|
| Alt Symbol |
MEM3, PARK17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vacuolar protein sorting 35 homolog (S. cerevisiae)
|
| Other Description |
hVPS35|maternal-embryonic 3|vacuolar protein sorting-associated protein 35
|
| Swissprots |
Q561W2 Q96QK1 Q9H016 Q9NZK2 Q9H8J0 Q9NVG2 Q9NX80 Q9H4P3 Q9NRS7 Q9H096
|
| Accessions |
EAW82683 EAW82684 Q96QK1 AF086051 AF175265 AAF89953 AF183418 AAG09687 AF186382 AAG40619 AF191298 AAF02778 AK000395 BAA91137 AK001614 BAA91790 AK023650 BAB14626 AK025774 AK223218 BAD96938 AL136888 CAB66822 AL512769 CAC21686 AM393740 CAL38615 AY007112 AAG01989 BC002414 AAH02414 BC010362 AAH10362 BC041367 BC093036 AAH93036 BM971213 BQ574179 BX647213 CAI46268 DB049686 XM_005256045 XP_005256102 XM_011523227 XP_011521529 NM_018206 NP_060676
|
| Function |
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved
|
| Subcellular Location |
Cytoplasm. Membrane; Peripheral membrane protein. Endosome {ECO:0000269|PubMed:15078903}. Early endosome {ECO:0000305}. Late endosome {ECO:0000305}. Note=Localizes to tubular profiles adjacent to endosomes. {ECO:0000269|PubMed:15078903}.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.
|