VPS35

Gene Symbol	VPS35
Entrez Gene	55737
Alt Symbol	MEM3, PARK17
Species	Human
Gene Type	protein-coding
Description	vacuolar protein sorting 35 homolog (S. cerevisiae)
Other Description	hVPS35|maternal-embryonic 3|vacuolar protein sorting-associated protein 35
Swissprots	Q561W2 Q96QK1 Q9H016 Q9NZK2 Q9H8J0 Q9NVG2 Q9NX80 Q9H4P3 Q9NRS7 Q9H096
Accessions	EAW82683 EAW82684 Q96QK1 AF086051 AF175265 AAF89953 AF183418 AAG09687 AF186382 AAG40619 AF191298 AAF02778 AK000395 BAA91137 AK001614 BAA91790 AK023650 BAB14626 AK025774 AK223218 BAD96938 AL136888 CAB66822 AL512769 CAC21686 AM393740 CAL38615 AY007112 AAG01989 BC002414 AAH02414 BC010362 AAH10362 BC041367 BC093036 AAH93036 BM971213 BQ574179 BX647213 CAI46268 DB049686 XM_005256045 XP_005256102 XM_011523227 XP_011521529 NM_018206 NP_060676
Function	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Endosome {ECO:0000269|PubMed:15078903}. Early endosome {ECO:0000305}. Late endosome {ECO:0000305}. Note=Localizes to tubular profiles adjacent to endosomes. {ECO:0000269|PubMed:15078903}.
Tissue Specificity	Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VPS35 full length protein - ab132953 from Abcam Category Protein Source Wheat germ Species Human

Human VPS35 peptide - ab23181 from Abcam Category Peptide Species Human

Human VPS35 protein fragment - ab163195 from Abcam Category Protein Source Wheat germ Species Human

VPS35 Antibody Blocking Peptide - LS-E25680 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human VPS35 Protein - H00055737-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human VPS35 Protein - H00055737-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

VPS35 blocking peptide - GTX10099-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

VPS35 Peptide - AC21-0510-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

VPS35 / MEM3 - H00055737-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VPS35 / MEM3 - H00055737-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VPS35 / MEM3 - H00055737-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

VPS35 / MEM3 - H00055737-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

VPS35 Peptide - 46-584P from ProSci Category Peptide Species Human

VPS35 fusion protein - Ag0340 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

VPS35 fusion protein - ag0333 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human VPS35, GST-tagged - VPS35-3678H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Vacuolar protein sorting-associated protein 35(VPS35) - CSB-YP839401HU CSB-EP839401HU CSB-BP839401HU CSB-MP839401HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

VPS35 Protein - abx164298 from Abbexa Category Protein Species Human, Mouse, Rat

Vacuolar protein sorting-associated protein 35 (VPS35) , Recombinant Protein - MBS1346990 from MyBioSource Category Protein Prices $2,760.00, $2,760.00, $3,215.00, $3,215.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

VPS35/MEM3, Peptide - MBS426803 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Bovine

VPS35 Protein - NBP2-13517PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

VPS35 Peptide, Human - M34GP17316H from Creative Peptides Category Peptide Source Synthetic. Species Human

VPS35 Blocking Peptide - CBP7506 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Bovine

VPS35 Immunizing peptide - orb16817 from Biorbyt Category Peptide

Recombinant Human VPS35 Protein (1-796 aa), His-MBP-tagged - VPS35-2750M from Creative Biomart Category Protein Source Baculovirus Species Human

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