Gene Symbol |
ERBB3
|
Entrez Gene |
2065
|
Alt Symbol |
ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
erb-b2 receptor tyrosine kinase 3
|
Other Description |
human epidermal growth factor receptor 3|proto-oncogene-like protein c-ErbB-3|receptor tyrosine-protein kinase erbB-3|tyrosine kinase-type cell surface receptor HER3|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
|
Swissprots |
B4DIK7 B4DV32 A8K6L6 Q9BUD7 P21860 E9PDT8
|
Accessions |
AAF86627 AAF86628 CCD32996 EAW96879 EAW96880 EAW96881 EAW96882 EAW96883 P21860 AA524528 AK124710 BAG54075 AK125028 BAG54127 AK291681 BAF84370 AK294719 BAG57868 AK295650 BAG58519 AK300909 BAG62544 AU100462 BC002706 AAH02706 BC041579 BC082992 AAH82992 BM837872 BT007226 AAP35890 BU674508 BX641868 DC344156 DC347955 M29366 AAA35790 M34309 AAA35979 S61953 AAB26935 U88357 AAC39857 U88358 AAC39858 U88359 AAC39859 U88360 AAC39860 NM_001005915 NP_001005915 NM_001982 NP_001973
|
Function |
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5. {ECO:0000269|PubMed:15358134}.
|
Subcellular Location |
Isoform 1: Cell membrane; Single-pass type I membrane protein.
|
Tissue Specificity |
Epithelial tissues and brain.
|
Top Pathways |
ErbB signaling pathway, Calcium signaling pathway, Endocytosis, MicroRNAs in cancer, Proteoglycans in cancer
|