ERBB3

Gene Symbol ERBB3
Entrez Gene 2065
Alt Symbol ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Species Human
Gene Type protein-coding
Description erb-b2 receptor tyrosine kinase 3
Other Description human epidermal growth factor receptor 3|proto-oncogene-like protein c-ErbB-3|receptor tyrosine-protein kinase erbB-3|tyrosine kinase-type cell surface receptor HER3|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Swissprots B4DIK7 B4DV32 A8K6L6 Q9BUD7 P21860 E9PDT8
Accessions AAF86627 AAF86628 CCD32996 EAW96879 EAW96880 EAW96881 EAW96882 EAW96883 P21860 AA524528 AK124710 BAG54075 AK125028 BAG54127 AK291681 BAF84370 AK294719 BAG57868 AK295650 BAG58519 AK300909 BAG62544 AU100462 BC002706 AAH02706 BC041579 BC082992 AAH82992 BM837872 BT007226 AAP35890 BU674508 BX641868 DC344156 DC347955 M29366 AAA35790 M34309 AAA35979 S61953 AAB26935 U88357 AAC39857 U88358 AAC39858 U88359 AAC39859 U88360 AAC39860 NM_001005915 NP_001005915 NM_001982 NP_001973
Function Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5. {ECO:0000269|PubMed:15358134}.
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Epithelial tissues and brain.
Top Pathways ErbB signaling pathway, Calcium signaling pathway, Endocytosis, MicroRNAs in cancer, Proteoglycans in cancer

Phospho-HER3/ErbB3 (Tyr1222) (50C2) Rabbit mAb - 4784 from Cell Signaling Technology

Prices $307.00, $719.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 50C2
Western blot analysis of MCF-7 and T47D cell lysates untreated or stimulated with Neuregulin (100 ng/ml) for 15 min, using Phospho-HER3/ErbB3 (Tyr1222) (50C2) Rabbit mAb (upper) and HER3/ErbB3 (1B2) Rabbit mAb #4754 (lower).

Phospho-HER3/ErbB3 (Tyr1328) (E1J1T) Rabbit mAb - 14525 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1J1T
Western blot analysis of extracts from T-47D cells, untreated (-) or treated (+) with Human Neuregulin-1 (hNRG-1) #5218 (100 ng/ml, 5 min), using Phospho-HER3/ErbB3 (Tyr1328) (E1J1T) Rabbit mAb (upper) and HER3/ErbB3 (1B2E) Rabbit mAb #4754 (lower).

Phospho-HER3/ErbB3 (Tyr1197) (C56E4) Rabbit mAb - 4561 from Cell Signaling Technology

Prices $297.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C56E4
Western blot analysis of extracts from T47D cells, untreated or treated with neuregulin (NRG), using Phospho-HER3/ErbB3 (Tyr1197) (C56E4) Rabbit mAb (upper) and HER3/ErbB3 (1B2) Rabbit mAb #4754 (lower).

Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb - 2842 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1B5
Western blot analysis of extracts from T-47D cells (serum starved overnight), untreated (-) or treated with Human Neuregulin-1 (hNRG-1) #5218 (100 ng/ml, 15 min; +), using Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb (upper) or HER3/ErbB3 (1B2E) Rabbit mAb #4754 (lower).

Phospho-HER3/ErbB3 (Tyr1289) (21D3) Rabbit mAb - 4791 from Cell Signaling Technology

Prices $307.00, $719.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 21D3
Western blot analysis of extracts from mIMCD-3 cells, untreated or treated with neuregulin-1 (100 ng/ml, 5 min) using Phospho-HER3/ErbB3 (Tyr1289) (21D3) RmAb.

HER3/ErbB3 (D22C5) XP ® Rabbit mAb - 12708 from Cell Signaling Technology

Prices $109.00, $282.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D22C5
Western blot analysis of extracts from MCF7 (HER3+) and MDA-MB-231 (HER3-) cells using HER3/ErbB3 (D22C5) XP ® Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

HER3/ErbB3 (1B2E) Rabbit mAb - 4754 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 1B2E
Western blot analysis of MCF7 and T47D cell lysates, using HER3/ErbB3 (1B2) Rabbit mAb.

Phospho-HER3/ErbB3 (Tyr1328) Antibody - 8017 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

ErbB-3 (C-17) - sc-285 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ErbB-3 (C-17) PE: sc-285 PE. Intracellular FCM analysis of fixed and permeabilized control (green line histogram) and ErbB-3 transfected (solid orange histogram) NIH/3T3 cells. Dotted pink histogram represents the isotype control, normal rabbit IgG: sc-3871.

ErbB-3 (G-4) - sc-7390 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-3 (G-4): sc-7390. Immunofluorescence staining of methanol-fixed NIH/3T3 cells transfected with ErbB-3 showing membrane localization.

ErbB-3 (RTJ.2) - sc-415 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-3 (RTJ.2) PE: sc-415 PE. Intracellular FCM analysis of fixed and permeabilized HEL 92.1.7 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

ErbB-3 (H-53) - sc-292557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ErbB-3 (H-53): sc-292557. Western blot analysis of ErbB-3 expression in non-transfected 293T: sc-117752 (A), human ErbB-3 transfected 293T: sc-111418 (B), NTERA-2 cl.D1 (C), MCF7 (D) and Jurkat (E) whole cell lysates.

ErbB-3 (SGP1) - sc-53279 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-3 (SGP1): sc-53279. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

ErbB-3 (5A12) - sc-81455 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
ErbB-3 (5A12): sc-81455. Western blot analysis of ErbB-3 expression in K-562 (A) and NTERA-2 cl.D1 (B) whole cell lysates.

ErbB-3 (2Q320) - sc-71067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ErbB-3 (2Q320): sc-71067. Western blot analysis of ErbB-3 expression in non-transfected: sc-117752 (A) and human ErbB-3 transfected: sc-111418 (B) 293T whole cell lysates.

ErbB-3 (11A4) - sc-81454 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
ErbB-3 (11A4): sc-81454. Western blot analysis of ErbB-3 expression in human ErbB-3 transfected NIH/3T3 whole cell lysate.

p-ErbB-3 (Tyr 1328) - sc-135654 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-ErbB-3 (Tyr 1328): sc-135654. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic and membrane localization.

Anti-ErbB 3 (phospho Y1197) antibody - ab138431 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ErbB 3 (phospho Y1197) antibody (ab138431) at 1/500 dilution + HepG2 cell extracts

Anti-ErbB 3 (phospho Y1197) antibody [EPR5806] - ab133444 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5806
All lanes : Anti-ErbB 3 (phospho Y1197) antibody [EPR5806] (ab133444) at 1/10000 dilutionLane 1 : SKBR3 cell lysate. Lane 2 : SKBR3 cell lysate treated with neuregulin.Lysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP conjugated antibody at 1/2000 dilution

Anti-ErbB 3 (phospho Y1222) antibody - ab62434 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human brain tissue using ab62434 at a 1/50 dilution, in the presence (right) and absence (left) of immunizing phosphopeptide.

Anti-ErbB 3 (phospho Y1222) antibody [EPR5807] - ab133445 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5807
All lanes : Anti-ErbB 3 (phospho Y1222) antibody [EPR5807] (ab133445) at 1/1000 dilutionLane 1 : SKBR3 cell lysateLane 2 : Lysate of SKBR3 cells treated with neuregulin.SecondaryGoat anti-rabbit HRP conjugated antibody at 1/2000 dilution

Anti-ErbB 3 (phospho Y1276) antibody [EPR5808(2)] - ab134900 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5808(2)
Equilibrium disassociation constant (KD)Learn more about KD Click here to learn more about KD

Anti-ErbB 3 (phospho Y1289) antibody - ab62435 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of HeLa cells using ab62435 at a 1/500 dilution, in the presence (right) and absence (left) of immunising phosphopeptide.

Anti-ErbB 3 (phospho Y1289) antibody [EPNCIR124] - ab133443 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPNCIR124
All lanes : Anti-ErbB 3 (phospho Y1289) antibody [EPNCIR124] (ab133443) at 1/10000 dilutionLane 1 : MCF7 cell lysateLane 2 : MCF7 cell lysate treated with neuregulinLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP conjugated antibody at 1/10000 dilution

Anti-ErbB 3 (phospho Y1289) antibody [EPR2325] - ab76469 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2325
All lanes : Anti-ErbB 3 (phospho Y1289) antibody [EPR2325] (ab76469) at 1/5000 dilutionLane 1 : SKBR3 cell lysate untreatedLane 2 : SKBR3 cell lysate treated with Neuregulin Lysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution
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