HTR2B

Gene Symbol HTR2B
Entrez Gene 3357
Alt Symbol 5-HT(2B), 5-HT2B
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
Other Description 5-HT 2B receptor|5-HT-2B|5-hydroxytryptamine 2B receptor|5-hydroxytryptamine receptor 2B|5-hydroxytryptamine receptor 2B variant b|serotonin receptor 2B
Swissprots Q6P523 Q62221 B2R9D5 Q53TI1 P41595
Accessions AAB31827 AAD39259 AAX93128 ACE96333 ACE96338 ACE96343 EAW70949 P41595 AK313741 BAG36482 AY114103 AAM78370 AY136751 AAN01277 BC063123 AAH63123 X77307 CAA54513 Z36748 CAA85319 XM_005246520 XP_005246577 XM_006712482 XP_006712545 XM_011511073 XP_011509375 NM_000867 NP_000858
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome {ECO:0000250}.
Tissue Specificity Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex. {ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856, ECO:0000269|PubMed:8882600}.
Top Pathways Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

SR-2B (C-6) - sc-376878 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SR-2B (C-6): sc-376878. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

SR-2B (H-95) - sc-25647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SR-2B (H-95): sc-25647. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic and membrane staining of glandular cells.

SR-2B (H-11) - sc-376834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SR-2B (H-11): sc-376834. Western blot analysis of SR-2B expression in SK-MEL-28 whole cell lysate.

SR-2B (I-20) - sc-15076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SR-2B (Y-15) - sc-15080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-2B (Y-15): sc-15080. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing apical membrane staining of glandular cells.

Anti-5HT2B Receptor antibody - ab102707 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-5HT2B Receptor antibody - Extracellular domain - ab194333 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-5HT2B Receptor antibody - Extracellular domain (ab194333) at 1/500 dilution + HepG2 cell lysate at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-HTR2B / 5-HT2B Receptor Antibody (N-Terminus) IHC-plus™ - LS-A1187 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR2B / 5-HT2B Receptor Antibody (Extracellular Domain) IHC-plus™ - LS-A1111 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR2B / 5-HT2B Receptor Antibody - LS-C95998 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody (aa415-442, AP) - LS-C222786 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody (aa415-442, APC) - LS-C222787 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody (aa415-442, Biotin) - LS-C222788 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody (clone 4A4) - LS-C197473 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A4
Detection limit for recombinant GST tagged HTR2B is 0.03 ng/ml as a capture antibody.

Anti-HTR2B / 5-HT2B Receptor Antibody (aa415-442, Azide-free, HRP) - LS-C222789 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody (His55) - LS-C177075 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SR-2B (H55) pAb in extracts from HT-29.

Anti-HTR2B / 5-HT2B Receptor Antibody (aa35-84) - LS-C109575 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HTR2B / 5-HT2B antibody LS-C109575 Western blot of 721_B cell lysate.

Anti-HTR2B / 5-HT2B Receptor Antibody (aa415-442, FITC) - LS-C222790 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody (aa233-282) - LS-C200061 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HepG2 cells using 5-HT-2B antibody.

Anti-HTR2B / 5-HT2B Receptor Antibody (aa415-442, PE) - LS-C222791 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody (aa6-55) - LS-C292077 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody (aa15-64) IHC-plus™ - LS-B9273 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HTR1B / 5-HT2B Receptor antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR2B / 5-HT2B Receptor Antibody (aa415-442) - LS-C329649 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody - LS-C341311 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2B / 5-HT2B Receptor Antibody (aa261-310) - LS-C119368 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using 5-HT-2B Antibody. The picture on the right is treated with the synthesized peptide.
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