| Gene Symbol |
HTR2B
|
| Entrez Gene |
3357
|
| Alt Symbol |
5-HT(2B), 5-HT2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
|
| Other Description |
5-HT 2B receptor|5-HT-2B|5-hydroxytryptamine 2B receptor|5-hydroxytryptamine receptor 2B|5-hydroxytryptamine receptor 2B variant b|serotonin receptor 2B
|
| Swissprots |
Q6P523 Q62221 B2R9D5 Q53TI1 P41595
|
| Accessions |
AAB31827 AAD39259 AAX93128 ACE96333 ACE96338 ACE96343 EAW70949 P41595 AK313741 BAG36482 AY114103 AAM78370 AY136751 AAN01277 BC063123 AAH63123 X77307 CAA54513 Z36748 CAA85319 XM_005246520 XP_005246577 XM_006712482 XP_006712545 XM_011511073 XP_011509375 NM_000867 NP_000858
|
| Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex. {ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856, ECO:0000269|PubMed:8882600}.
|
| Top Pathways |
Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction
|