HTR2B

Gene Symbol	HTR2B
Entrez Gene	3357
Alt Symbol	5-HT(2B), 5-HT2B
Species	Human
Gene Type	protein-coding
Description	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
Other Description	5-HT 2B receptor|5-HT-2B|5-hydroxytryptamine 2B receptor|5-hydroxytryptamine receptor 2B|5-hydroxytryptamine receptor 2B variant b|serotonin receptor 2B
Swissprots	Q6P523 Q62221 B2R9D5 Q53TI1 P41595
Accessions	AAB31827 AAD39259 AAX93128 ACE96333 ACE96338 ACE96343 EAW70949 P41595 AK313741 BAG36482 AY114103 AAM78370 AY136751 AAN01277 BC063123 AAH63123 X77307 CAA54513 Z36748 CAA85319 XM_005246520 XP_005246577 XM_006712482 XP_006712545 XM_011511073 XP_011509375 NM_000867 NP_000858
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome {ECO:0000250}.
Tissue Specificity	Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex. {ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856, ECO:0000269|PubMed:8882600}.
Top Pathways	Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human 5HT2B Receptor full length protein - ab152463 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human 5HT2B Receptor peptide - ab24286 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human 5HT2B Receptor protein fragment - ab114546 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human 5HT2B Receptor protein fragment - ab152464 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

HTR2B / 5-HT2B Receptor Blocking Peptide - LS-E770 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR2B / 5-HT2B Receptor Antibody Blocking Peptide - LS-E10703 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR2B / 5-HT2B Receptor Antibody Blocking Peptide - LS-E28166 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTR2B / 5-HT2B Receptor Antibody Blocking Peptide - LS-E28139 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTR2B / 5-HT2B Receptor Antibody Blocking Peptide - LS-E28140 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human 5-HT2B Protein - H00003357-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human 5-HT2B Protein - H00003357-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human 5-HT2B Protein - H00003357-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human 5-HT2B Protein - H00003357-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

HTR2B-Antibody-C-term-E423-Blocking-peptide - BP11124a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Serotonin receptor 2B Blocking Peptide - 33R-7748 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

5-HT2B Blocking Peptide - abx062759 from Abbexa Category Peptide Species Human

Serotonin receptor 2B (HTR2B) - H00003357-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

Serotonin receptor 2B (HTR2B) - H00003357-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Serotonin receptor 2B (HTR2B) - H00003357-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Serotonin receptor 2B (HTR2B) - H00003357-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

Serotonin receptor 2B (HTR2B) - H00003357-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Serotonin receptor 2B (HTR2B) - H00003357-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Serotonin receptor 2B (HTR2B) - H00003357-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Serotonin receptor 2B (HTR2B) - H00003357-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Serotonin receptor 2B (HTR2B) - H00003357-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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