HTR2B
| Gene Symbol | HTR2B |
|---|---|
| Entrez Gene | 3357 |
| Alt Symbol | 5-HT(2B), 5-HT2B |
| Species | Human |
| Gene Type | protein-coding |
| Description | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled |
| Other Description | 5-HT 2B receptor|5-HT-2B|5-hydroxytryptamine 2B receptor|5-hydroxytryptamine receptor 2B|5-hydroxytryptamine receptor 2B variant b|serotonin receptor 2B |
| Swissprots | Q6P523 Q62221 B2R9D5 Q53TI1 P41595 |
| Accessions | AAB31827 AAD39259 AAX93128 ACE96333 ACE96338 ACE96343 EAW70949 P41595 AK313741 BAG36482 AY114103 AAM78370 AY136751 AAN01277 BC063123 AAH63123 X77307 CAA54513 Z36748 CAA85319 XM_005246520 XP_005246577 XM_006712482 XP_006712545 XM_011511073 XP_011509375 NM_000867 NP_000858 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex. {ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856, ECO:0000269|PubMed:8882600}. |
| Top Pathways | Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction |
SR-2B CRISPR/Cas9 KO Plasmid (h) - sc-402574 from Santa Cruz Biotechnology
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SR-2B HDR Plasmid (h) - sc-402574-HDR from Santa Cruz Biotechnology
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SR-2B Double Nickase Plasmid (h) - sc-402574-NIC from Santa Cruz Biotechnology
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SR-2B Double Nickase Plasmid (h2) - sc-402574-NIC-2 from Santa Cruz Biotechnology
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SR-2B CRISPR Activation Plasmid (h) - sc-402574-ACT from Santa Cruz Biotechnology
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SR-2B CRISPR Activation Plasmid (h2) - sc-402574-ACT-2 from Santa Cruz Biotechnology
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SR-2B Lentiviral Activation Particles (h) - sc-402574-LAC from Santa Cruz Biotechnology
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SR-2B Lentiviral Activation Particles (h2) - sc-402574-LAC-2 from Santa Cruz Biotechnology
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SR-2B siRNA (h) - sc-42233 from Santa Cruz Biotechnology
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SR-2B shRNA Plasmid (h) - sc-42233-SH from Santa Cruz Biotechnology
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SR-2B shRNA (h) Lentiviral Particles - sc-42233-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU052881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10395 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10395 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02791 from Sigma-Aldrich
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HTR2B siRNA (Human) - CRH2287 from Cohesion Biosciences
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5-HT2B RNAi - H00003357-R02 from Novus Biologicals
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HTR2B - MBS8226407 from MyBioSource
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shRNA set against Human HTR2B (NM_000867.4) - SHH315925 from Creative biogene
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Human HTR2B siRNA - orb262789 from Biorbyt
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HTR2B shRNA Plasmid (Human) - CHH2287 from Cohesion Biosciences
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HTR2B miRNA 3'UTR clone - MiUTR3H-03893 from Creative biogene
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