Gene Symbol | LHPP |
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Entrez Gene | 64077 |
Alt Symbol | HDHD2B |
Species | Human |
Gene Type | protein-coding |
Description | phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
Other Description | hLHPP |
Swissprots | Q9H008 Q5VUV9 Q2TBE9 Q5VUW0 B3KP20 |
Accessions | EAW49264 EAW49265 EAW49266 EAW49267 EAW49268 EAW49269 Q9H008 AK055532 BAG51532 BC007324 BC073172 BC110344 AAI10345 BC113629 AAI13630 BC113631 AAI13632 EF151005 HQ258160 ADR82914 XM_005270025 XP_005270082 XM_005270026 XP_005270083 XM_005270027 XP_005270084 XM_006717943 XP_006718006 XM_011540055 XP_011538357 XM_011540056 XP_011538358 XM_011540057 XP_011538359 XM_011540058 XP_011538360 XR_945797 NM_001167880 NP_001161352 NM_022126 NP_071409 |
Function | Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16430861}. Nucleus {ECO:0000269|PubMed:16430861}. |
Tissue Specificity | Expressed in brain, and at lower levels in liver and kidney. Detected in thyroid (at protein level). Expressed in liver, kidney and moderately in brain. {ECO:0000269|PubMed:12801912, ECO:0000269|PubMed:16430861}. |
Top Pathways | Oxidative phosphorylation |
LHPP CRISPR/Cas9 KO Plasmid (h) - sc-408945 from Santa Cruz Biotechnology
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LHPP HDR Plasmid (h) - sc-408945-HDR from Santa Cruz Biotechnology
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LHPP Double Nickase Plasmid (h) - sc-408945-NIC from Santa Cruz Biotechnology
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LHPP Double Nickase Plasmid (h2) - sc-408945-NIC-2 from Santa Cruz Biotechnology
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LHPP CRISPR Activation Plasmid (h) - sc-408945-ACT from Santa Cruz Biotechnology
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LHPP CRISPR Activation Plasmid (h2) - sc-408945-ACT-2 from Santa Cruz Biotechnology
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LHPP Lentiviral Activation Particles (h) - sc-408945-LAC from Santa Cruz Biotechnology
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LHPP Lentiviral Activation Particles (h2) - sc-408945-LAC-2 from Santa Cruz Biotechnology
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LHPP siRNA (h) - sc-90377 from Santa Cruz Biotechnology
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LHPP shRNA Plasmid (h) - sc-90377-SH from Santa Cruz Biotechnology
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LHPP shRNA (h) Lentiviral Particles - sc-90377-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU003831 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0296 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0297 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0295 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11691 from Sigma-Aldrich
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LHPP siRNA (Human) - CRJ1903 from Cohesion Biosciences
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shRNA set against Human LHPP (NM_022126.3) - SHH330083 from Creative biogene
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Human LHPP siRNA - orb272404 from Biorbyt
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LHPP shRNA Plasmid (Human) - CHJ1903 from Cohesion Biosciences
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LHPP miRNA 3'UTR clone - MiUTR3H-15309 from Creative biogene
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