Gene Symbol | HAND2 |
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Entrez Gene | 9464 |
Alt Symbol | DHAND2, Hed, Thing2, bHLHa26, dHand |
Species | Human |
Gene Type | protein-coding |
Description | heart and neural crest derivatives expressed 2 |
Other Description | basic helix-loop-helix transcription factor HAND2|class A basic helix-loop-helix protein 26|deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2|heart- and neural crest derivatives-expressed protein 2 |
Swissprots | P97833 Q494T1 B6ECG9 O95301 O95300 P61296 |
Accessions | AAD13186 EAX04749 EAX04750 P61296 AF087940 AAD13185 AK122739 BAG53697 BC101406 AAI01407 BC101974 AAI01975 BC109383 AAI09384 BF313018 FJ226608 ACI42790 NM_021973 NP_068808 |
Function | Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. |
Tissue Specificity | Heart. |
dHAND (A-12) - sc-398167 from Santa Cruz Biotechnology
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dHAND (H-110) - sc-22818 from Santa Cruz Biotechnology
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dHAND (G-16) - sc-9411 from Santa Cruz Biotechnology
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dHAND (M-19) - sc-9409 from Santa Cruz Biotechnology
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dHAND (HAND2C1a) - sc-130629 from Santa Cruz Biotechnology
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Anti-HAND2 antibody - ab10131 from Abcam
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Anti-HAND2 antibody - ab56590 from Abcam
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Anti-HAND2 antibody - Carboxyterminal end - ab60037 from Abcam
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Anti-DHAND / HAND2 Antibody - LS-C36591 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (aa187-200) - LS-C54957 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody - LS-C67174 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (Internal) - LS-C209872 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (clone HAND2C1a) - LS-C184635 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (aa81-110, AP) - LS-C222705 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (aa81-110, APC) - LS-C222706 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (aa81-110, Azide-free, HRP) - LS-C222708 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (aa81-110, Biotin) - LS-C222707 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (aa81-110, FITC) - LS-C222709 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (aa81-110, PE) - LS-C222711 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (C-Terminus, AP) - LS-C225562 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (C-Terminus, APC) - LS-C225563 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (C-Terminus, Biotin) - LS-C225564 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (C-Terminus, FITC) - LS-C225565 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (C-Terminus, Azide-free, HRP) - LS-C225566 from LifeSpan Bioscience
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Anti-DHAND / HAND2 Antibody (C-Terminus) - LS-C134909 from LifeSpan Bioscience
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