HAND2

Gene Symbol	HAND2
Entrez Gene	9464
Alt Symbol	DHAND2, Hed, Thing2, bHLHa26, dHand
Species	Human
Gene Type	protein-coding
Description	heart and neural crest derivatives expressed 2
Other Description	basic helix-loop-helix transcription factor HAND2|class A basic helix-loop-helix protein 26|deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2|heart- and neural crest derivatives-expressed protein 2
Swissprots	P97833 Q494T1 B6ECG9 O95301 O95300 P61296
Accessions	AAD13186 EAX04749 EAX04750 P61296 AF087940 AAD13185 AK122739 BAG53697 BC101406 AAI01407 BC101974 AAI01975 BC109383 AAI09384 BF313018 FJ226608 ACI42790 NM_021973 NP_068808
Function	Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}.
Tissue Specificity	Heart.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

dHAND CRISPR/Cas9 KO Plasmid (h) - sc-402017 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

dHAND HDR Plasmid (h) - sc-402017-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dHAND Double Nickase Plasmid (h) - sc-402017-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dHAND Double Nickase Plasmid (h2) - sc-402017-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dHAND CRISPR Activation Plasmid (h) - sc-402017-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

dHAND CRISPR Activation Plasmid (h2) - sc-402017-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

dHAND Lentiviral Activation Particles (h) - sc-402017-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dHAND Lentiviral Activation Particles (h2) - sc-402017-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

dHAND siRNA (h) - sc-37920 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

dHAND shRNA Plasmid (h) - sc-37920-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

dHAND shRNA (h) Lentiviral Particles - sc-37920-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HAND2 RNAi - H00009464-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU157941 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9863 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9863 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06407 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr06407

HAND2 siRNA (Human) - CRH6279 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HAND2 RNAi - H00009464-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HAND2 - MBS8222379 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human HAND2 (NM_021973.2) - SHH310241 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human HAND2(NM_021973.2) - SHH113699 from Creative biogene Category siRNA Species Reactivities Human

HAND2 shRNA Plasmid (Human) - CHH6279 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

HAND2 miRNA 3'UTR clone - MiUTR1H-04370 from Creative biogene Species Reactivities Human

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