| Gene Symbol |
CCDC53
|
| Entrez Gene |
51019
|
| Alt Symbol |
CGI-116
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coiled-coil domain containing 53
|
| Other Description |
WASH complex subunit CCDC53|coiled-coil domain-containing protein 53
|
| Swissprots |
B2RC74 Q9Y3C0 Q53FF0 Q96QK0 Q6IAI4
|
| Accessions |
EAW97687 Q9Y3C0 AF151874 AAD34111 AF155655 AAF67012 AI739611 AK223339 BAD97059 AK314970 BAG37471 BC010889 AAH10889 BX356987 CR457171 CAG33452 DB452335 HQ448683 ADQ33161 XM_011538423 XP_011536725 NM_001301107 NP_001288036 NM_016053 NP_057137
|
| Function |
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093}.
|
| Subcellular Location |
Early endosome {ECO:0000305}.
|