| Gene Symbol | Pik3r1 |
|---|---|
| Entrez Gene | 18708 |
| Alt Symbol | PI3K, p50alpha, p55alpha, p85alpha |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) |
| Other Description | PI3-kinase subunit p85-alpha|PI3K regulatory subunit alpha|phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha|phosphatidylinositol 3-kinase regulatory subunit alpha |
| Swissprots | Q8K3B3 P26450 |
| Accessions | EDL00772 P26450 AI838690 AK046259 AK049798 BAC33923 AK138868 BAE23803 AK160493 AK164783 BAE37914 AK171366 BB647657 BC002168 AAH02168 BC026146 AAH26146 BC051106 AAH51106 BM963795 BY276314 CB519962 CF169061 M60651 AAA39886 U50413 AAC52847 U50414 AAC52848 XM_006517569 XP_006517632 XM_006517570 XP_006517633 NM_001024955 NP_001020126 NM_001077495 NP_001070963 |
| Function | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926). {ECO:0000250, ECO:0000269|PubMed:20348926}. |
| Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |