Pik3r1

Gene Symbol	Pik3r1
Entrez Gene	18708
Alt Symbol	PI3K, p50alpha, p55alpha, p85alpha
Species	Mouse
Gene Type	protein-coding
Description	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
Other Description	PI3-kinase subunit p85-alpha|PI3K regulatory subunit alpha|phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha|phosphatidylinositol 3-kinase regulatory subunit alpha
Swissprots	Q8K3B3 P26450
Accessions	EDL00772 P26450 AI838690 AK046259 AK049798 BAC33923 AK138868 BAE23803 AK160493 AK164783 BAE37914 AK171366 BB647657 BC002168 AAH02168 BC026146 AAH26146 BC051106 AAH51106 BM963795 BY276314 CB519962 CF169061 M60651 AAA39886 U50413 AAC52847 U50414 AAC52848 XM_006517569 XP_006517632 XM_006517570 XP_006517633 NM_001024955 NP_001020126 NM_001077495 NP_001070963
Function	Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926). {ECO:0000250, ECO:0000269|PubMed:20348926}.
Top Pathways	Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PI3 Kinase p85α siRNA I (Mouse Specific) - 6912 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

PI 3-kinase p85α CRISPR/Cas9 KO Plasmid (m) - sc-422233 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

PI 3-kinase p85α HDR Plasmid (m) - sc-422233-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

PI 3-kinase p85α Double Nickase Plasmid (m) - sc-422233-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

PI 3-kinase p85α Double Nickase Plasmid (m2) - sc-422233-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

PI 3-kinase p85α CRISPR Activation Plasmid (m) - sc-422233-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

PI 3-kinase p85α CRISPR Activation Plasmid (m2) - sc-422233-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

PI 3-kinase p85α Lentiviral Activation Particles (m) - sc-422233-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

PI 3-kinase p85α Lentiviral Activation Particles (m2) - sc-422233-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

PI 3-kinase p85α siRNA (m) - sc-36218 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

PI 3-kinase p85α shRNA Plasmid (m) - sc-36218-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

PI 3-kinase p85α shRNA (m) Lentiviral Particles - sc-36218-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU187151 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN38734 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38734 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PIK3R1 siRNA (Mouse) - CRM3062 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse PIK3R1 (NM_001024955.1) - SHH375776 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Pik3r1(NM_001024955.1) - SHR114594 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Pik3r1(NM_001077495.1) - SHR114708 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse PIK3R1 siRNA - orb282538 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

PIK3R1 shRNA Plasmid (Mouse) - CHM3062 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

PIK3R1 miRNA 3'UTR clone - MiUTR1M-09214 from Creative biogene Species Reactivities Mouse

PIK3R1 miRNA 3'UTR clone - MiUTR1M-09215 from Creative biogene Species Reactivities Mouse

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