MLXIP

Gene Symbol MLXIP
Entrez Gene 22877
Alt Symbol MIR, MONDOA, bHLHe36
Species Human
Gene Type protein-coding
Description MLX interacting protein
Other Description MLX-interacting protein|Mlx interactor|class E basic helix-loop-helix protein 36|transcriptional activator MondoA
Swissprots Q8IXP1 O94945 Q8WYA5 Q7LC47 Q8WVQ0 A7MBN0 Q9HAP2 Q8TAH9
Accessions EAW98304 EAW98305 EAW98306 Q9HAP2 AB020674 BAA74890 AF245480 AAL55689 AF245481 AAL55690 AF312918 AAG34121 AW996647 BC017656 AAH17656 BC028309 AAH28309 BC039704 AAH39704 BC069272 BC151841 AAI51842 BE207198 BM007462 BM461435 BM558759 BM857835 BQ218664 BQ445885 CA426212 XM_006719290 XP_006719353 XM_006719291 XP_006719354 XM_006719292 XP_006719355 XM_006719293 XP_006719356 XM_006719294 XP_006719357 XR_944508 XR_944509 NM_014938 NP_055753
Function Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Mitochondrion outer membrane {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Tissue Specificity Widely expressed in adult tissues. Most abundant in skeletal muscle. {ECO:0000269|PubMed:11073985}.
Top Pathways Non-alcoholic fatty liver disease (NAFLD)

MondoA (G-12) - sc-133396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

MondoA (P-14) - sc-133397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MondoA (P-14): sc-133397. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes.

MondoA (S-14) - sc-133398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

MondoA (H-47) - sc-292075 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-MLX-interacting protein antibody - ab94783 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MLX-interacting protein antibody (ab94783) at 1 µg/ml (in 5% skim milk / PBS buffer) + PANC-1 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MLX-interacting protein antibody - ab77294 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MLX-interacting protein antibody (ab77294) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 3 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 4 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 5 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 6 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-MLX-interacting protein antibody - ab176688 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MLX-interacting protein antibody (ab176688) at 0.04 µg/mlLane 1 : HeLa lysate at 50 µgLane 2 : HeLa lysate at 15 µgLane 3 : Jurkat lysate at 50 µgLane 4 : 293T lysate at 50 µgdeveloped using the ECL technique

Anti-MLXIP / MONDOA Antibody (aa79-108, APC) - LS-C237692 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLXIP / MONDOA Antibody (aa79-108, FITC) - LS-C237695 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLXIP / MONDOA Antibody (aa79-108, PE) - LS-C237696 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLXIP / MONDOA Antibody (aa79-108, Biotin) - LS-C237693 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLXIP / MONDOA Antibody (aa79-108, Azide-free, HRP) - LS-C248827 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLXIP / MONDOA Antibody (aa79-108) - LS-C323028 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLXIP / MONDOA Antibody (aa395-444) - LS-C110091 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MLXIP antibody LS-C110091 Western blot of PANC1 cell lysate.

Anti-MLXIP / MONDOA Antibody (C-Terminus) - LS-C135035 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MLXIP antibody LS-C135035 Western blot of Jurkat lysate.

Anti-MLXIP / MONDOA Antibody (aa869-919) - LS-C289892 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human MondoA by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), Jurkat (J; 50 ug) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-MondoA antibody used for WB at 0.04 ug/ml (A) and 0.4 ug/ml (B) and used for IP at 6 ug/mg lysate. MondoA was also immunoprecipitated by rabbit anti-MondoA antibody BL11421, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 3 seconds (B).

Anti-MLXIP / MONDOA Antibody (aa79-108, AP) - LS-C237691 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MLXIP / MONDOA Antibody (aa72-100) IHC-plus™ - LS-B12245 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

MLXIP Antibody - NBP1-88617 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: MLXIP Antibody [NBP1-88617] - Staining of human skeletal muscle shows strong cytoplasmic positivity.

MLXIP Antibody (5F3) - H00022877-M06-100ug from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5F3

ANTI-MLXIP(N-TERMINAL) antibody produced in rabbit - SAB1306992 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MLXIP (N-term): <B>Cat. No. SAB1306992</B>: MLXIP Antibody (N-term) western blot analysis in Mouse lung tissue lysates (35 μg/lane).

Anti-MLXIP antibody produced in rabbit - SAB2104303 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MLXIP, antibody produced in rabbit: <B>Cat. No. SAB2104303</B>: Immunoblotting analysis of MLXIP in PANC1 cell lysate with MLXIP anitbody at 1 μg/mL.

Anti-MLXIP antibody produced in rabbit - HPA023084 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MLXIP: <B>Cat. No. HPA023084</B>: Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity.

Monoclonal Anti-MLXIP antibody produced in mouse - SAB1412807 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5F3
<B>Immunoblotting</B><BR/>Anti-MLXIP:<B>Cat. No. SAB1412807</B>: Antibody concentration: 1 μg/mL. Immunofluorescence band of ~36.4 kDa using immunogen protein lysate.

MLXIP antibody - middle region (ARP35891_P050) - ARP35891_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more