| Gene Symbol |
MLXIP
|
| Entrez Gene |
22877
|
| Alt Symbol |
MIR, MONDOA, bHLHe36
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MLX interacting protein
|
| Other Description |
MLX-interacting protein|Mlx interactor|class E basic helix-loop-helix protein 36|transcriptional activator MondoA
|
| Swissprots |
Q8IXP1 O94945 Q8WYA5 Q7LC47 Q8WVQ0 A7MBN0 Q9HAP2 Q8TAH9
|
| Accessions |
EAW98304 EAW98305 EAW98306 Q9HAP2 AB020674 BAA74890 AF245480 AAL55689 AF245481 AAL55690 AF312918 AAG34121 AW996647 BC017656 AAH17656 BC028309 AAH28309 BC039704 AAH39704 BC069272 BC151841 AAI51842 BE207198 BM007462 BM461435 BM558759 BM857835 BQ218664 BQ445885 CA426212 XM_006719290 XP_006719353 XM_006719291 XP_006719354 XM_006719292 XP_006719355 XM_006719293 XP_006719356 XM_006719294 XP_006719357 XR_944508 XR_944509 NM_014938 NP_055753
|
| Function |
Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Mitochondrion outer membrane {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
|
| Tissue Specificity |
Widely expressed in adult tissues. Most abundant in skeletal muscle. {ECO:0000269|PubMed:11073985}.
|
| Top Pathways |
Non-alcoholic fatty liver disease (NAFLD)
|