MLXIP

Gene Symbol MLXIP
Entrez Gene 22877
Alt Symbol MIR, MONDOA, bHLHe36
Species Human
Gene Type protein-coding
Description MLX interacting protein
Other Description MLX-interacting protein|Mlx interactor|class E basic helix-loop-helix protein 36|transcriptional activator MondoA
Swissprots Q8IXP1 O94945 Q8WYA5 Q7LC47 Q8WVQ0 A7MBN0 Q9HAP2 Q8TAH9
Accessions EAW98304 EAW98305 EAW98306 Q9HAP2 AB020674 BAA74890 AF245480 AAL55689 AF245481 AAL55690 AF312918 AAG34121 AW996647 BC017656 AAH17656 BC028309 AAH28309 BC039704 AAH39704 BC069272 BC151841 AAI51842 BE207198 BM007462 BM461435 BM558759 BM857835 BQ218664 BQ445885 CA426212 XM_006719290 XP_006719353 XM_006719291 XP_006719354 XM_006719292 XP_006719355 XM_006719293 XP_006719356 XM_006719294 XP_006719357 XR_944508 XR_944509 NM_014938 NP_055753
Function Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Mitochondrion outer membrane {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Tissue Specificity Widely expressed in adult tissues. Most abundant in skeletal muscle. {ECO:0000269|PubMed:11073985}.
Top Pathways Non-alcoholic fatty liver disease (NAFLD)

MondoA CRISPR/Cas9 KO Plasmid (h) - sc-407619 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MondoA HDR Plasmid (h) - sc-407619-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MondoA Double Nickase Plasmid (h) - sc-407619-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MondoA Double Nickase Plasmid (h2) - sc-407619-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MondoA CRISPR Activation Plasmid (h) - sc-407619-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MondoA CRISPR Activation Plasmid (h2) - sc-407619-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MondoA Lentiviral Activation Particles (h) - sc-407619-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MondoA Lentiviral Activation Particles (h2) - sc-407619-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MondoA siRNA (h) - sc-95771 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MondoA shRNA Plasmid (h) - sc-95771-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MondoA shRNA (h) Lentiviral Particles - sc-95771-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU018361 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14412 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14412 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11697 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11697

MLXIP siRNA (Human) - CRH7834 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MLXIP (NM_014938.4) - SHH342704 from Creative biogene

Category siRNA
Species Reactivities Human

Human MLXIP siRNA - orb268336 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MLXIP shRNA Plasmid (Human) - CHH7834 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MLXIP miRNA 3'UTR clone - MiUTR4H-TG05545 from Creative biogene

Species Reactivities Human
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