| Gene Symbol |
NR2E3
|
| Entrez Gene |
10002
|
| Alt Symbol |
ESCS, PNR, RNR, RP37, rd7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 2, group E, member 3
|
| Other Description |
photoreceptor-specific nuclear receptor|retina-specific nuclear receptor
|
| Swissprots |
Q9UHM4 B6ZGU0 Q9Y5X4
|
| Accessions |
AAD28302 AKE32080 CAB82769 EAW77876 EAW77877 Q9Y5X4 AB307710 BAH02301 AF121129 AAD28301 AF148128 AAF22227 AL711747 AW080977 BC041421 AAH41421 BU732726 HQ692847 ADZ17358 XM_011521146 XP_011519448 NM_014249 NP_055064 NM_016346 NP_057430 NM_001281446
|
| Function |
Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. {ECO:0000269|PubMed:15689355, ECO:0000269|PubMed:24069298}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:15689355}.
|
| Tissue Specificity |
Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside. {ECO:0000269|PubMed:15689355}.
|