CD2AP

Gene Symbol	CD2AP
Entrez Gene	23607
Alt Symbol	CMS
Species	Human
Gene Type	protein-coding
Description	CD2-associated protein
Other Description	Cas ligand with multiple Src homology 3 (SH3) domains|adapter protein CMS|cas ligand with multiple SH3 domains
Swissprots	Q9UG97 Q9Y5K6 Q5VYA3 A6NL34
Accessions	EAX04319 Q9Y5K6 AF146277 AAD34595 AF164377 AAF80495 AJ420469 AL050105 CAB43274 BC069444 AAH69444 BU679191 DA040834 XM_005248976 XP_005249033 XM_005248977 XP_005249034 XM_011514449 XP_011512751 NM_012120 NP_036252
Function	Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. {ECO:0000269|PubMed:15800069}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase. {ECO:0000250, ECO:0000269|PubMed:15800069}.
Tissue Specificity	Widely expressed in fetal and adult tissues.
Top Pathways	Bacterial invasion of epithelial cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD2AP peptide - ab32740 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CD2 Associated Protein Protein - abx065841 from Abbexa Category Protein Source E.coli Species Human

Recombinant CD2 Associated Protein (CD2AP) - RPL298Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant CD2 Associated Protein (CD2AP) - RPL298Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant CD2 Associated Protein (CD2AP) - RPL298Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human CD2-associated protein(CD2AP) - CSB-YP004914HU CSB-EP004914HU CSB-BP004914HU CSB-MP004914HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CD2AP (350-639) - sc-4348 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

CD2AP Protein - abx164462 from Abbexa Category Protein Species Human, Mouse, Rat

CD2-associated protein - TP310191 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CD2 Associated Protein (CD2AP), Recombinant Protein - MBS2018570 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

CD2-associated protein (CD2AP), Recombinant Protein - MBS1370178 from MyBioSource Category Protein Prices $1,435.00, $1,435.00, $1,665.00, $1,665.00, $2,435.00, $2,435.00, $2,880.00, $2,880.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CD2AP Recombinant Protein Antigen - NBP1-90626PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CD2AP Recombinant Protein Antigen - NBP1-90625PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CD2AP Peptide, Human - M34GP02729H from Creative Peptides Category Peptide Source Synthetic. Species Human

CD2AP Recombinant Protein (OPCD02003) - OPCD02003 from Aviva Systems Biology Category Protein Source E.coli Species Human

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