CD2AP

Gene Symbol CD2AP
Entrez Gene 23607
Alt Symbol CMS
Species Human
Gene Type protein-coding
Description CD2-associated protein
Other Description Cas ligand with multiple Src homology 3 (SH3) domains|adapter protein CMS|cas ligand with multiple SH3 domains
Swissprots Q9UG97 Q9Y5K6 Q5VYA3 A6NL34
Accessions EAX04319 Q9Y5K6 AF146277 AAD34595 AF164377 AAF80495 AJ420469 AL050105 CAB43274 BC069444 AAH69444 BU679191 DA040834 XM_005248976 XP_005249033 XM_005248977 XP_005249034 XM_011514449 XP_011512751 NM_012120 NP_036252
Function Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. {ECO:0000269|PubMed:15800069}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase. {ECO:0000250, ECO:0000269|PubMed:15800069}.
Tissue Specificity Widely expressed in fetal and adult tissues.
Top Pathways Bacterial invasion of epithelial cells

CD2AP (A599) Antibody - 5478 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using CD2AP (A599) Antibody.

CD2AP Antibody - 2135 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of K562, A431 and COS cells, using CD2AP Antibody.

CD2AP (H-290) - sc-9137 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD2AP siRNA (h): sc-29984. Western blot analysis of CD2AP expression in non-transfected control (A) and CD2AP siRNA transfected (B) HeLa cells. Blot probed with CD2AP (H-290): sc-9137. Lamin A/C (H-110): sc-20681 used as specificity and loading control.

CD2AP (N-20) - sc-8763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD2AP (N-20): sc-8763. Western blot analysis of CD2AP expression in MOLT-4 whole cell lysate.

CD2AP (B-4) - sc-25272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD2AP (B-4): sc-25272. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

CD2AP (C-16) - sc-8764 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD2AP (C-16): sc-8764. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic and membrane staining of glandular cells.

CD2AP (K-20) - sc-34228 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD2AP (K-20): sc-34228. Western blot analysis of CD2AP expression in MOLT-4 (A) and A431 (B) whole cell lysates.

Anti-CD2AP antibody - ab32741 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD2AP antibody (ab32741) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate (ab27252)Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lysates/proteins at 20 µg per lane.SecondaryIR Dye 680 Conjugated Goat Anti-Rabbit IgG (H&L) at 1/15000 dilutionPerformed under reducing conditions.

Anti-CD2AP antibody - ab84829 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab84829 at a 1/200 dilution showing cytoplasmic staining of CD2AP in formalin-fixed, paraffin-embedded kidney tissue sections by immunohistochemistry.

Anti-CD2AP Antibody (phospho-Tyr4) - LS-C209419 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CD2AP Antibody (aa368-623, Biotin) - LS-C301014 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD2AP Antibody (aa149-429, Biotin) - LS-C300694 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD2AP Antibody (aa368-623, FITC) - LS-C303541 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD2AP Antibody (aa149-429, FITC) - LS-C302106 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD2AP Antibody (C-Terminus) - LS-C137097 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CD2AP Antibody IHC-plus™ - LS-B10060 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CD2AP antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10060 concentration 5 ug/ml.

Anti-CD2AP Antibody (aa149-429) - LS-C293275 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CD2AP.

Anti-CD2AP Antibody (aa368-623) - LS-C293272 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CD2AP.

CD2AP Antibody - AF4474 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
Western Blot CD2AP Antibody

CD2AP Antibody - NBP1-90625 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CD2AP Antibody - NBP1-90626 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CD2AP Antibody [NBP1-90626] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

CD2AP Polyclonal Antibody - bs-0512R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat lung tissue labeled with Anti-CD2AP Polyclonal Antibody (bs-0512R) , Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining

Anti-CD2AP antibody produced in rabbit - HPA003267 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CD2AP: <B>Cat. No. HPA003267</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human stomach tissue showing cytoplasmic and/or membranous staining of glandular cells.

Anti-CD2AP antibody produced in rabbit - HPA003326 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CD2AP: <B>Cat. No. HPA003326</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic and/or membranous staining of glandular cells.

CD2AP antibody - GTX106235 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-CD2AP antibody used in ICC/IF. GTX106235
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