| Gene Symbol | CD2AP |
|---|---|
| Entrez Gene | 23607 |
| Alt Symbol | CMS |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD2-associated protein |
| Other Description | Cas ligand with multiple Src homology 3 (SH3) domains|adapter protein CMS|cas ligand with multiple SH3 domains |
| Swissprots | Q9UG97 Q9Y5K6 Q5VYA3 A6NL34 |
| Accessions | EAX04319 Q9Y5K6 AF146277 AAD34595 AF164377 AAF80495 AJ420469 AL050105 CAB43274 BC069444 AAH69444 BU679191 DA040834 XM_005248976 XP_005249033 XM_005248977 XP_005249034 XM_011514449 XP_011512751 NM_012120 NP_036252 |
| Function | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. {ECO:0000269|PubMed:15800069}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase. {ECO:0000250, ECO:0000269|PubMed:15800069}. |
| Tissue Specificity | Widely expressed in fetal and adult tissues. |
| Top Pathways | Bacterial invasion of epithelial cells |
CD2AP CRISPR/Cas9 KO Plasmid (h) - sc-401218 from Santa Cruz Biotechnology
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CD2AP HDR Plasmid (h) - sc-401218-HDR from Santa Cruz Biotechnology
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CD2AP Double Nickase Plasmid (h) - sc-401218-NIC from Santa Cruz Biotechnology
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CD2AP Double Nickase Plasmid (h2) - sc-401218-NIC-2 from Santa Cruz Biotechnology
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CD2AP CRISPR Activation Plasmid (h) - sc-401218-ACT from Santa Cruz Biotechnology
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CD2AP CRISPR Activation Plasmid (h2) - sc-401218-ACT-2 from Santa Cruz Biotechnology
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CD2AP Lentiviral Activation Particles (h) - sc-401218-LAC from Santa Cruz Biotechnology
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CD2AP Lentiviral Activation Particles (h2) - sc-401218-LAC-2 from Santa Cruz Biotechnology
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CD2AP siRNA (h) - sc-29984 from Santa Cruz Biotechnology
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CD2AP shRNA Plasmid (h) - sc-29984-SH from Santa Cruz Biotechnology
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CD2AP shRNA (h) Lentiviral Particles - sc-29984-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU015821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5710 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5710 from Sigma-Aldrich
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CD2AP siRNA (Human) - CRH8393 from Cohesion Biosciences
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CD2AP - MBS8229274 from MyBioSource
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shRNA set against Human CD2AP (NM_012120.2) - SHH258865 from Creative biogene
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shRNA set against Human CD2AP(NM_012120.2) - SHG155563 from Creative biogene
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Human CD2AP siRNA - orb268895 from Biorbyt
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CD2AP shRNA Plasmid (Human) - CHH8393 from Cohesion Biosciences
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CD2AP miRNA 3'UTR clone - MiUTR1H-01863 from Creative biogene
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