| Gene Symbol |
TIAM2
|
| Entrez Gene |
26230
|
| Alt Symbol |
STEF, TIAM-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
T-cell lymphoma invasion and metastasis 2
|
| Other Description |
SIF and TIAM1-like exchange factor|T-lymphoma invasion and metastasis-inducing protein 2
|
| Swissprots |
B2RP56 Q9UKV9 Q9UFG6 Q6ZUP9 Q8IVF5 Q9UKW0 C9JZV2 Q6NXN9
|
| Accessions |
EAW47692 EAW47693 Q8IVF5 AF120323 AAF05900 AF120324 AAF05901 AF195656 AAF03902 AK123859 BAG53973 AK125459 BAC86170 AK299723 BAH13110 AK302860 BAH13824 AL122086 CAB59259 BC022469 BC066979 AAH66979 BC137275 AAI37276 BP199501 NM_001010927 NP_001010927 NM_012454 NP_036586
|
| Function |
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis. {ECO:0000269|PubMed:10512681}.
|