TIAM2
| Gene Symbol | TIAM2 |
|---|---|
| Entrez Gene | 26230 |
| Alt Symbol | STEF, TIAM-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | T-cell lymphoma invasion and metastasis 2 |
| Other Description | SIF and TIAM1-like exchange factor|T-lymphoma invasion and metastasis-inducing protein 2 |
| Swissprots | B2RP56 Q9UKV9 Q9UFG6 Q6ZUP9 Q8IVF5 Q9UKW0 C9JZV2 Q6NXN9 |
| Accessions | EAW47692 EAW47693 Q8IVF5 AF120323 AAF05900 AF120324 AAF05901 AF195656 AAF03902 AK123859 BAG53973 AK125459 BAC86170 AK299723 BAH13110 AK302860 BAH13824 AL122086 CAB59259 BC022469 BC066979 AAH66979 BC137275 AAI37276 BP199501 NM_001010927 NP_001010927 NM_012454 NP_036586 |
| Function | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites. {ECO:0000250}. |
| Tissue Specificity | Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis. {ECO:0000269|PubMed:10512681}. |
Tiam2 CRISPR/Cas9 KO Plasmid (h) - sc-404326 from Santa Cruz Biotechnology
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Tiam2 HDR Plasmid (h) - sc-404326-HDR from Santa Cruz Biotechnology
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Tiam2 Double Nickase Plasmid (h) - sc-404326-NIC from Santa Cruz Biotechnology
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Tiam2 Double Nickase Plasmid (h2) - sc-404326-NIC-2 from Santa Cruz Biotechnology
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Tiam2 CRISPR Activation Plasmid (h) - sc-404326-ACT from Santa Cruz Biotechnology
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Tiam2 CRISPR Activation Plasmid (h2) - sc-404326-ACT-2 from Santa Cruz Biotechnology
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Tiam2 Lentiviral Activation Particles (h) - sc-404326-LAC from Santa Cruz Biotechnology
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Tiam2 Lentiviral Activation Particles (h2) - sc-404326-LAC-2 from Santa Cruz Biotechnology
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Tiam2 siRNA (h) - sc-41736 from Santa Cruz Biotechnology
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Tiam2 shRNA Plasmid (h) - sc-41736-SH from Santa Cruz Biotechnology
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Tiam2 shRNA (h) Lentiviral Particles - sc-41736-V from Santa Cruz Biotechnology
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TIAM2 RNAi - H00026230-R01 from Novus Biologicals
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MISSION® esiRNA - EHU159011 from Sigma-Aldrich
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MISSION® esiRNA - EHU087741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21341 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04408 from Sigma-Aldrich
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TIAM2 siRNA (Human) - CRH8766 from Cohesion Biosciences
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TIAM2 RNAi - H00026230-R02 from Novus Biologicals
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TIAM2 - MBS8230467 from MyBioSource
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shRNA set against Human Tiam2 (NM_001010927.2) - SHH427221 from Creative biogene
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shRNA set against Human TIAM2(NM_012454.3) - SHL070560 from Creative biogene
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TIAM2 shRNA Plasmid (Human) - CHH8766 from Cohesion Biosciences
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TIAM2 miRNA 3'UTR clone - MiUTR1H-10405 from Creative biogene
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TIAM2 miRNA 3'UTR clone - MiUTR1H-10406 from Creative biogene
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