TIAM2

Gene Symbol TIAM2
Entrez Gene 26230
Alt Symbol STEF, TIAM-2
Species Human
Gene Type protein-coding
Description T-cell lymphoma invasion and metastasis 2
Other Description SIF and TIAM1-like exchange factor|T-lymphoma invasion and metastasis-inducing protein 2
Swissprots B2RP56 Q9UKV9 Q9UFG6 Q6ZUP9 Q8IVF5 Q9UKW0 C9JZV2 Q6NXN9
Accessions EAW47692 EAW47693 Q8IVF5 AF120323 AAF05900 AF120324 AAF05901 AF195656 AAF03902 AK123859 BAG53973 AK125459 BAC86170 AK299723 BAH13110 AK302860 BAH13824 AL122086 CAB59259 BC022469 BC066979 AAH66979 BC137275 AAI37276 BP199501 NM_001010927 NP_001010927 NM_012454 NP_036586
Function Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites. {ECO:0000250}.
Tissue Specificity Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis. {ECO:0000269|PubMed:10512681}.

Tiam2 (C-5) - sc-514090 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tiam2 (C-5): sc-514090. Western blot analysis of Tiam2 expression in rat brain (A), rat cerebellum (B) and mouse brain (C) tissue extracts.

Tiam2 (N-19) - sc-13303 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tiam2 (N-19): sc-13303. Western blot analysis of Tiam2 expression in rat cerebellum tissue extract.

Tiam2 (P-17) - sc-13304 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tiam2 (P-17): sc-13304. Western blot analysis of Tiam2 expression in rat cerebellum tissue extract.

Anti-TIAM2 antibody - ab93839 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TIAM2 antibody (ab93839) at 1 µg/mlLane 1 : Brain (Mouse) Tissue LysateLane 2 : Mouse Hippocampus Tissue LysateLane 3 : Rat Cortex Tissue Lysate Lane 4 : Cerebellum Mouse Tissue Lysate Lane 5 : Rat Olfactory Bulb LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TIAM2 antibody - ab103578 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TIAM2 antibody (ab103578) at 5 µg/ml + K562 cell lysate at 50 µg

Anti-TIAM2 antibody - ab57033 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57033 TIAM2 antibody at 1ug/ml.

Anti-TIAM2 antibody - ab134577 from Abcam

Prices $242.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-TIAM2 antibody [EPR16838] - ab199426 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16838
All lanes : Anti-TIAM2 antibody [EPR16838] (ab199426) at 1/10000 dilutionLane 1 : K562 (Human chronic myelogenous leukemia cells from bone marrow) whole cell lysateLane 2 : 293 (Human embryonic kidney) whole cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-TIAM2 Antibody (aa1899-1911) - LS-C154808 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TIAM2 Antibody (aa357-385, AP) - LS-C241788 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TIAM2 Antibody (aa357-385, APC) - LS-C241789 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TIAM2 Antibody (aa357-385, FITC) - LS-C241792 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TIAM2 Antibody (aa357-385, Biotin) - LS-C241790 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TIAM2 Antibody (aa357-385, PE) - LS-C241794 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TIAM2 Antibody (aa357-385, Azide-free, HRP) - LS-C247065 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TIAM2 Antibody (aa356-385) - LS-C325724 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TIAM2 Antibody (aa357-385) - LS-C161871 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TIAM2 Antibody western blot of mouse liver tissue lysates (35 ug/lane). The TIAM2 antibody detected the TIAM2 protein (arrow).

Anti-TIAM2 Antibody (aa9-19) IHC-plus™ - LS-B10530 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Human, Testis: Formalin-Fixed Paraffin-Embedded (FFPE)

TIAM2 Antibody - H00026230-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

TIAM2 Antibody - NBP1-80713 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: TIAM2 Antibody [NBP1-80713] - Staining of human cell line A-431 shows localization to nucleoplasm.

TIAM2 Antibody - NBP1-80714 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TIAM2 Antibody [NBP1-80714] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10<br/>Lane 2: Tonsil

TIAM2 Antibody (3C1) - H00026230-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C1
Western Blot: TIAM2 Antibody (3C1) [H00026230-M01] - Analysis of TIAM2 expression in transfected 293T cell line by TIAM2 monoclonal antibody (M01), clone 3C1.Lane 1: TIAM2 transfected lysate(70.8 KDa).Lane 2: Non-transfected lysate.

TIAM2 Antibody - H00026230-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: TIAM2 Antibody [H00026230-D01P] - Analysis of TIAM2 expression in K-562.

TIAM2 Antibody - H00026230-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: TIAM2 Antibody [H00026230-A01] - TIAM2 polyclonal antibody (A01), Lot # 050926JC01 Western Blot analysis of TIAM2 expression in 293 ( Cat # L026V1 ).

TIAM2 Antibody - H00026230-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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