| Gene Symbol |
CITED2
|
| Entrez Gene |
10370
|
| Alt Symbol |
ASD8, MRG-1, MRG1, P35SRJ, VSD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
|
| Other Description |
MSG-related protein 1|MSG1-related gene 1|cbp/p300-interacting transactivator 2|melanocyte-specific gene 1-related gene 1
|
| Swissprots |
Q5VTF4 Q99967 O95426
|
| Accessions |
AAF01263 AAF01264 ADL14510 EAW47891 EAW47892 EAW47893 EAW47894 EAW47895 Q99967 AA400897 AA767624 AF109161 AAD10055 AI087283 BC004377 AAH04377 BG900380 BI763038 BM763150 BM851650 CF126189 DQ893296 ABM84222 DQ896731 ABM87730 U65093 AAC51114 NM_001168388 NP_001161860 NM_001168389 NP_001161861 NM_006079 NP_006070
|
| Function |
Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral pla
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:8901575, ECO:0000269|PubMed:9887100}. Note=Colocalizes with EP300 in dot-like structures.
|