Gene Symbol | CITED2 |
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Entrez Gene | 10370 |
Alt Symbol | ASD8, MRG-1, MRG1, P35SRJ, VSD2 |
Species | Human |
Gene Type | protein-coding |
Description | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
Other Description | MSG-related protein 1|MSG1-related gene 1|cbp/p300-interacting transactivator 2|melanocyte-specific gene 1-related gene 1 |
Swissprots | Q5VTF4 Q99967 O95426 |
Accessions | AAF01263 AAF01264 ADL14510 EAW47891 EAW47892 EAW47893 EAW47894 EAW47895 Q99967 AA400897 AA767624 AF109161 AAD10055 AI087283 BC004377 AAH04377 BG900380 BI763038 BM763150 BM851650 CF126189 DQ893296 ABM84222 DQ896731 ABM87730 U65093 AAC51114 NM_001168388 NP_001161860 NM_001168389 NP_001161861 NM_006079 NP_006070 |
Function | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral pla |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:8901575, ECO:0000269|PubMed:9887100}. Note=Colocalizes with EP300 in dot-like structures. |
MRG1 CRISPR/Cas9 KO Plasmid (h) - sc-403052 from Santa Cruz Biotechnology
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MRG1 HDR Plasmid (h) - sc-403052-HDR from Santa Cruz Biotechnology
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MRG1 Double Nickase Plasmid (h) - sc-403052-NIC from Santa Cruz Biotechnology
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MRG1 Double Nickase Plasmid (h2) - sc-403052-NIC-2 from Santa Cruz Biotechnology
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MRG1 CRISPR Activation Plasmid (h) - sc-403052-ACT from Santa Cruz Biotechnology
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MRG1 CRISPR Activation Plasmid (h2) - sc-403052-ACT-2 from Santa Cruz Biotechnology
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MRG1 Lentiviral Activation Particles (h) - sc-403052-LAC from Santa Cruz Biotechnology
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MRG1 Lentiviral Activation Particles (h2) - sc-403052-LAC-2 from Santa Cruz Biotechnology
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MRG1 siRNA (h) - sc-35959 from Santa Cruz Biotechnology
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MRG1 shRNA Plasmid (h) - sc-35959-SH from Santa Cruz Biotechnology
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MRG1 shRNA (h) Lentiviral Particles - sc-35959-V from Santa Cruz Biotechnology
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Cited-2 RNAi - H00010370-R01 from Novus Biologicals
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MISSION® esiRNA - EHU049321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1413 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1414 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1412 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1413 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1412 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1414 from Sigma-Aldrich
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CITED2 siRNA (Human) - CRH7027 from Cohesion Biosciences
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CITED2 - MBS8203538 from MyBioSource
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Human CITED2 siRNA - orb267529 from Biorbyt
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CITED2 shRNA Plasmid (Human) - CHH7027 from Cohesion Biosciences
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CITED2 miRNA 3'UTR clone - MiUTR3H-05429 from Creative biogene
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