Gene Symbol | CITED2 |
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Entrez Gene | 10370 |
Alt Symbol | ASD8, MRG-1, MRG1, P35SRJ, VSD2 |
Species | Human |
Gene Type | protein-coding |
Description | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
Other Description | MSG-related protein 1|MSG1-related gene 1|cbp/p300-interacting transactivator 2|melanocyte-specific gene 1-related gene 1 |
Swissprots | Q5VTF4 Q99967 O95426 |
Accessions | AAF01263 AAF01264 ADL14510 EAW47891 EAW47892 EAW47893 EAW47894 EAW47895 Q99967 AA400897 AA767624 AF109161 AAD10055 AI087283 BC004377 AAH04377 BG900380 BI763038 BM763150 BM851650 CF126189 DQ893296 ABM84222 DQ896731 ABM87730 U65093 AAC51114 NM_001168388 NP_001161860 NM_001168389 NP_001161861 NM_006079 NP_006070 |
Function | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral pla |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:8901575, ECO:0000269|PubMed:9887100}. Note=Colocalizes with EP300 in dot-like structures. |
MRG1 (N-15) - sc-9669 from Santa Cruz Biotechnology
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MRG1 (S-17) - sc-9670 from Santa Cruz Biotechnology
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MRG1 (JA22) - sc-21795 from Santa Cruz Biotechnology
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MRG1 (H-220) - sc-25375 from Santa Cruz Biotechnology
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Anti-CITED2 antibody - ab99335 from Abcam
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Anti-CITED2 antibody - ab76037 from Abcam
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Anti-CITED2 antibody - ab184145 from Abcam
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Anti-CITED2 antibody - ab172539 from Abcam
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Anti-CITED2 antibody [EPR3416(2)] - ab108345 from Abcam
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Anti-CITED2 antibody [JA22] - ab5155 from Abcam
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Anti-CITED2 antibody - N-terminal - ab189946 from Abcam
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Anti-CITED2 Antibody (Internal) - LS-C47568 from LifeSpan Bioscience
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Anti-CITED2 Antibody (C-Terminus) - LS-C79336 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa1-269, clone 11n47) - LS-C184204 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa207-234, APC) - LS-C213313 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa207-234, FITC) - LS-C213315 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa207-234, Biotin) - LS-C213314 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa207-234, AP) - LS-C213312 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa207-234, Azide-free, HRP) - LS-C213317 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa55-104) - LS-C80129 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa207-234, PE) - LS-C213318 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa207-234) - LS-C320405 from LifeSpan Bioscience
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Anti-CITED2 Antibody (N-Terminus) - LS-C80228 from LifeSpan Bioscience
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Anti-CITED2 Antibody (Internal, clone EPR3416(2)) - LS-C138092 from LifeSpan Bioscience
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Anti-CITED2 Antibody (aa207-234) - LS-C168786 from LifeSpan Bioscience
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