Gene Symbol | ITPKC |
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Entrez Gene | 80271 |
Alt Symbol | IP3-3KC, IP3KC |
Species | Human |
Gene Type | protein-coding |
Description | inositol-trisphosphate 3-kinase C |
Other Description | IP3 3-kinase C|IP3K C|InsP 3 kinase C|inositol 1,4,5-trisphosphate 3-kinase C|insP 3-kinase C |
Swissprots | Q96DU7 Q9UE25 Q9Y475 |
Accessions | EAW56992 EAW56993 Q96DU7 AJ290975 CAC40815 AK024596 BC026903 BC060788 AAH60788 D38169 BAA22524 Y11999 CAA72728 XM_006723404 XP_006723467 XR_243961 NM_025194 NP_079470 |
Function | Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12747803}. Cytoplasm {ECO:0000269|PubMed:12747803}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. |
Tissue Specificity | Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain. {ECO:0000269|PubMed:11085927}. |
Top Pathways | Calcium signaling pathway, Inositol phosphate metabolism, Phosphatidylinositol signaling system |
IP3KC CRISPR/Cas9 KO Plasmid (h) - sc-408964 from Santa Cruz Biotechnology
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IP3KC HDR Plasmid (h) - sc-408964-HDR from Santa Cruz Biotechnology
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IP3KC Double Nickase Plasmid (h) - sc-408964-NIC from Santa Cruz Biotechnology
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IP3KC Double Nickase Plasmid (h2) - sc-408964-NIC-2 from Santa Cruz Biotechnology
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IP3KC CRISPR Activation Plasmid (h) - sc-408964-ACT from Santa Cruz Biotechnology
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IP3KC CRISPR Activation Plasmid (h2) - sc-408964-ACT-2 from Santa Cruz Biotechnology
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IP3KC Lentiviral Activation Particles (h) - sc-408964-LAC from Santa Cruz Biotechnology
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IP3KC Lentiviral Activation Particles (h2) - sc-408964-LAC-2 from Santa Cruz Biotechnology
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IP3KC siRNA (h) - sc-39068 from Santa Cruz Biotechnology
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IP3KC shRNA Plasmid (h) - sc-39068-SH from Santa Cruz Biotechnology
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IP3KC shRNA (h) Lentiviral Particles - sc-39068-V from Santa Cruz Biotechnology
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IP3KC RNAi - H00080271-R02 from Novus Biologicals
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MISSION® esiRNA - EHU153721 from Sigma-Aldrich
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MISSION® siRNA - SIHK1002 from Sigma-Aldrich
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MISSION® siRNA - SIHK1000 from Sigma-Aldrich
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MISSION® siRNA - SIHK1001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10837 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10837 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08961 from Sigma-Aldrich
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ITPKC siRNA (Human) - CRJ2833 from Cohesion Biosciences
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ITPKC, siRNA - MBS8212449 from MyBioSource
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shRNA set against Human ITPKC (NM_025194.2) - SHH321661 from Creative biogene
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shRNA set against Human ITPKC(NM_025194.2) - SHL184818 from Creative biogene
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Human ITPKC siRNA - orb273334 from Biorbyt
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ITPKC shRNA Plasmid (Human) - CHJ2833 from Cohesion Biosciences
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