| Gene Symbol |
PRC1
|
| Entrez Gene |
9055
|
| Alt Symbol |
ASE1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein regulator of cytokinesis 1
|
| Other Description |
anaphase spindle elongation 1 homolog|protein regulating cytokinesis 1
|
| Swissprots |
B4DLR1 H9KV59 O43663 Q9BSB6 A6NC44
|
| Accessions |
CAM84944 CAM84945 CAM84946 EAX02134 EAX02135 EAX02136 EAX02137 EAX02138 O43663 AF044588 AAC02688 AK297117 BAG59623 AK304094 BAG65000 AK312600 BC003138 AAH03138 BC005140 AAH05140 BG773441 BG823292 BU634391 BX457401 BX647317 DA655494 DQ892933 ABM83859 DQ896182 ABM87181 DW423775 XM_005254987 XP_005255044 XM_006720759 XP_006720822 XM_006720760 XP_006720823 XM_011522187 XP_011520489 XM_011522188 XP_011520490 XM_011522189 XP_011520491 XM_011522190 XP_011520492 XM_011522191 XP_011520493 XM_011522192 XP_011520494 NM_001267580 NP_001254509 NM_003981 NP_003972 NM_199413 NP_955445 NM_199414
|
| Function |
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis.
|
![Western Blot: PRC1 Overexpression Lysate (Adult Normal) [NBL1-14729] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PRC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9589_PRC1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14729-img0002.jpg)