ELL

Gene Symbol ELL
Entrez Gene 8178
Alt Symbol C19orf17, ELL1, MEN, PPP1R68
Species Human
Gene Type protein-coding
Description elongation factor RNA polymerase II
Other Description ELL gene (11-19 lysine-rich leukemia gene)|RNA polymerase II elongation factor ELL|eleven-nineteen lysine-rich leukemia protein|protein phosphatase 1, regulatory subunit 68
Swissprots P55199
Accessions AAC28752 EAW84707 EAW84708 P55199 AB208794 BAD92031 AF157562 AAD45322 AK225481 AK293105 BAF85794 AK309878 AL136771 CAB66705 BC010010 BC033673 BC049195 AAH49195 BC064558 BC108256 BI458899 U16282 AAA57120 XM_011528330 XP_011526632 XR_936207 NM_006532 NP_006523
Function Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:000
Subcellular Location Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Tissue Specificity Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.

ELL (D7N6U) Rabbit mAb - 14468 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7N6U
Western blot analysis of extracts from various cell lines using ELL (D7N6U) Rabbit mAb.

ELL (H-180) - sc-28702 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ELL (H-180): sc-28702. Western blot analysis of ELL expression in non-transfected: sc-117752 (A) and human ELL transfected: sc-115994 (B) 293T whole cell lysates.

ELL (B-4) - sc-398959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ELL (B-4): sc-398959. Western blot analysis of ELL expression in non-transfected 293T: sc-117752 (A), human ELL transfected 293T: sc-115994 (B), JAR (C) and Caki-1 (D) whole cell lysates.

ELL (G-17) - sc-30727 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ELL (G-17): sc-30727. Western blot analysis of ELL expression in mouse skeletal tissue extract.

ELL (C-15) - sc-30728 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ELL (L-20) - sc-18387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ELL (L-20): sc-18387. Western blot analysis of ELL expression in non-transfected: sc-117752 (A) and human ELL transfected: sc-115994 (B) 293T whole cell lysates.

ELL (N-20) - sc-30726 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ELL (2316C1a) - sc-81264 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ELL (2316C1a): sc-81264 Western Blot analysis of human recombinant ELL fusion protein.

Anti-ELL antibody - ab64824 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ELL antibody (ab64824) at 1/500 dilutionLane 1 : Jurkat cell extract at 5-30ug with no immunizing peptideLane 2 : HeLa cell extract at 5-30ug with no immunizing peptideLane 3 : HeLa cell extract at 5-30ug with immunizing peptide at 5-10ug at 10 µg

Anti-ELL antibody - ab168672 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-ELL antibody (ab168672) at 1/500 dilutionLane 1 : ELL transfected 293T lysateLane 2 : Non-transfected 293T lysate Lysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-ELL antibody - ab102775 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ELL antibody (ab102775) at 1/100 dilution + Mouse testis tissue lysate at 35 µg

Anti-ELL antibody [2316C1a] - ab54408 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2316C1a
Anti-ELL antibody [2316C1a] (ab54408) + immunised recombinant protein

Anti-ELL / MEN Antibody - LS-C65251 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-ELL / MEN Antibody (clone 2316C1a) - LS-C184542 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2316C1a

Anti-ELL / MEN Antibody (aa516-545, AP) - LS-C222388 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELL / MEN Antibody (aa516-545, Biotin) - LS-C222389 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELL / MEN Antibody (aa516-545, APC) - LS-C222390 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELL / MEN Antibody (aa516-545, FITC) - LS-C222391 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELL / MEN Antibody (aa431-480) - LS-C109555 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELL antibody LS-C109555 Western blot of PANC1 cell lysate.

Anti-ELL / MEN Antibody (aa516-545, Azide-free, HRP) - LS-C222392 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELL / MEN Antibody (N-Terminus) - LS-C31337 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ELL antibody LS-C31337 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.

Anti-ELL / MEN Antibody (aa551-600) - LS-C31334 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ELL antibody LS-C31334 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-ELL / MEN Antibody (aa516-545, PE) - LS-C222393 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ELL / MEN Antibody (Asp125) - LS-C176784 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ELL (D125) pAb in extracts from Jurkat cells.

Anti-ELL / MEN Antibody (aa516-545, APC) - LS-C222395 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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