| Gene Symbol |
ELL
|
| Entrez Gene |
8178
|
| Alt Symbol |
C19orf17, ELL1, MEN, PPP1R68
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
elongation factor RNA polymerase II
|
| Other Description |
ELL gene (11-19 lysine-rich leukemia gene)|RNA polymerase II elongation factor ELL|eleven-nineteen lysine-rich leukemia protein|protein phosphatase 1, regulatory subunit 68
|
| Swissprots |
P55199
|
| Accessions |
AAC28752 EAW84707 EAW84708 P55199 AB208794 BAD92031 AF157562 AAD45322 AK225481 AK293105 BAF85794 AK309878 AL136771 CAB66705 BC010010 BC033673 BC049195 AAH49195 BC064558 BC108256 BI458899 U16282 AAA57120 XM_011528330 XP_011526632 XR_936207 NM_006532 NP_006523
|
| Function |
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:000
|
| Subcellular Location |
Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
|
| Tissue Specificity |
Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.
|
![Western Blot: ELL Overexpression Lysate (Adult Normal) [NBL1-10236] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ELL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6694_ELL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10236-img0002.jpg)