ELL

Gene Symbol ELL
Entrez Gene 8178
Alt Symbol C19orf17, ELL1, MEN, PPP1R68
Species Human
Gene Type protein-coding
Description elongation factor RNA polymerase II
Other Description ELL gene (11-19 lysine-rich leukemia gene)|RNA polymerase II elongation factor ELL|eleven-nineteen lysine-rich leukemia protein|protein phosphatase 1, regulatory subunit 68
Swissprots P55199
Accessions AAC28752 EAW84707 EAW84708 P55199 AB208794 BAD92031 AF157562 AAD45322 AK225481 AK293105 BAF85794 AK309878 AL136771 CAB66705 BC010010 BC033673 BC049195 AAH49195 BC064558 BC108256 BI458899 U16282 AAA57120 XM_011528330 XP_011526632 XR_936207 NM_006532 NP_006523
Function Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:000
Subcellular Location Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with EAF2 to nuclear speckles. Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Tissue Specificity Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.

ELL CRISPR/Cas9 KO Plasmid (h) - sc-404799 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELL HDR Plasmid (h) - sc-404799-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELL Double Nickase Plasmid (h) - sc-404799-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELL Double Nickase Plasmid (h2) - sc-404799-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELL CRISPR Activation Plasmid (h) - sc-404799-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELL CRISPR Activation Plasmid (h2) - sc-404799-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELL Lentiviral Activation Particles (h) - sc-404799-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELL Lentiviral Activation Particles (h2) - sc-404799-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELL siRNA (h) - sc-38041 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ELL shRNA Plasmid (h) - sc-38041-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ELL shRNA (h) Lentiviral Particles - sc-38041-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ELL RNAi - H00008178-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU130221 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7809 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7809 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11025 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11025

ELL siRNA (Human) - CRH5387 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ELL - MBS8225095 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ELL (NM_006532.3) - SHH285113 from Creative biogene

Category siRNA
Species Reactivities Human

ELL shRNA Plasmid (Human) - CHH5387 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ELL miRNA 3'UTR clone - MiUTR4H-TG03051 from Creative biogene

Species Reactivities Human
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